Regulation of Selenium Metabolism and Transport
Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells utilize it to synthesize the selenoproteins most important to them, creating a selenoprotein hierarchy in the cell. The liver is the central organ for selenium regulation and pr...
Saved in:
| Published in: | Annual review of nutrition Vol. 35; pp. 109 - 134 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
17.07.2015
|
| Subjects: | |
| ISSN: | 1545-4312 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells utilize it to synthesize the selenoproteins most important to them, creating a selenoprotein hierarchy in the cell. The liver is the central organ for selenium regulation and produces excretory selenium forms to regulate whole-body selenium. It responds to selenium deficiency by curtailing excretion and secreting selenoprotein P (Sepp1) into the plasma at the expense of its intracellular selenoproteins. Plasma Sepp1 is distributed to tissues in relation to their expression of the Sepp1 receptor apolipoprotein E receptor-2, creating a tissue selenium hierarchy. N-terminal Sepp1 forms are taken up in the renal proximal tubule by another receptor, megalin. Thus, the regulated whole-body pool of selenium is shifted to needy cells and then to vital selenoproteins in them to supply selenium where it is needed, creating a whole-body selenoprotein hierarchy. |
|---|---|
| AbstractList | Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells utilize it to synthesize the selenoproteins most important to them, creating a selenoprotein hierarchy in the cell. The liver is the central organ for selenium regulation and produces excretory selenium forms to regulate whole-body selenium. It responds to selenium deficiency by curtailing excretion and secreting selenoprotein P (Sepp1) into the plasma at the expense of its intracellular selenoproteins. Plasma Sepp1 is distributed to tissues in relation to their expression of the Sepp1 receptor apolipoprotein E receptor-2, creating a tissue selenium hierarchy. N-terminal Sepp1 forms are taken up in the renal proximal tubule by another receptor, megalin. Thus, the regulated whole-body pool of selenium is shifted to needy cells and then to vital selenoproteins in them to supply selenium where it is needed, creating a whole-body selenoprotein hierarchy. |
| Author | Hill, Kristina E Burk, Raymond F |
| Author_xml | – sequence: 1 givenname: Raymond F surname: Burk fullname: Burk, Raymond F email: raymond.burk@vanderbilt.edu, kristina.hill@vanderbilt.edu organization: Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0252; email: raymond.burk@vanderbilt.edu , kristina.hill@vanderbilt.edu – sequence: 2 givenname: Kristina E surname: Hill fullname: Hill, Kristina E |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25974694$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j81KAzEYRYMo9kdfQQZXbmK__DdLKVaFiqB1PSSdb2RkJqnJRPDtLVhX5y4OF86MnIYYkJBrBreMSb1wIZSE3zSUMVEwzDBJQUiu4IRMmZKKSsH4hMxy_gQAK4Q4JxOurJHayilZvOJH6d3YxVDFtnrDHkNXhuoZR-dj3-WhcqGptsmFvI9pvCBnreszXh45J-_r--3qkW5eHp5WdxvqpGQj1UZxq1FLBuisWTJoNBgOfqcaBUtAzR1T3qPXFnRrrRKH6bnyO-la0_A5ufn73af4VTCP9dDlHfa9CxhLrpm2hnNmtTioV0e1-AGbep-6waWf-j-S_wIloFZs |
| CitedBy_id | crossref_primary_10_1007_s42000_019_00112_w crossref_primary_10_1053_j_gastro_2020_12_059 crossref_primary_10_1155_2022_7009863 crossref_primary_10_3390_ijms242115992 crossref_primary_10_3390_antiox10040596 crossref_primary_10_3390_biom11081078 crossref_primary_10_1007_s12011_025_04719_6 crossref_primary_10_2903_j_efsa_2018_5386 crossref_primary_10_3390_nu7085297 crossref_primary_10_1016_j_mce_2021_111335 crossref_primary_10_31083_j_fbl2802041 crossref_primary_10_3389_fendo_2022_892672 crossref_primary_10_3390_metabo12040274 crossref_primary_10_3390_nu8020080 crossref_primary_10_3390_nu12082424 crossref_primary_10_3389_fcell_2025_1604575 crossref_primary_10_3390_nu14020342 crossref_primary_10_1016_j_forsciint_2021_110892 crossref_primary_10_3390_antiox11020298 crossref_primary_10_1038_s42255_020_0224_7 crossref_primary_10_1016_j_envres_2021_111734 crossref_primary_10_1016_j_aquatox_2017_03_009 crossref_primary_10_3390_nu12010002 crossref_primary_10_1002_jsfa_14367 crossref_primary_10_1038_s41390_018_0180_z crossref_primary_10_1016_j_intimp_2021_107790 crossref_primary_10_1016_j_fbio_2024_103997 crossref_primary_10_3390_molecules30010050 crossref_primary_10_3390_life10080121 crossref_primary_10_1016_j_rvsc_2025_105556 crossref_primary_10_1007_s12011_020_02204_w crossref_primary_10_1016_j_gene_2023_147461 crossref_primary_10_1016_j_rvsc_2023_06_018 crossref_primary_10_1016_j_tifs_2016_11_012 crossref_primary_10_1007_s44174_025_00445_8 crossref_primary_10_1016_j_ecoenv_2023_114589 crossref_primary_10_3390_antiox11020394 crossref_primary_10_1186_s12889_023_15614_x crossref_primary_10_1038_s41598_025_87917_5 crossref_primary_10_1016_j_biochi_2022_03_010 crossref_primary_10_1093_jn_nxac016 crossref_primary_10_1080_20477724_2023_2186079 crossref_primary_10_1016_j_bcp_2021_114799 crossref_primary_10_1016_j_fbio_2023_103018 crossref_primary_10_1093_mtomcs_mfaa008 crossref_primary_10_3390_genes11040440 crossref_primary_10_3390_ijms24119704 crossref_primary_10_1016_j_jbc_2023_105009 crossref_primary_10_1016_j_abb_2016_08_003 crossref_primary_10_1016_j_tcb_2023_06_002 crossref_primary_10_1016_j_livsci_2021_104783 crossref_primary_10_3390_nu13020619 crossref_primary_10_1039_D4SC05788K crossref_primary_10_1093_jb_mvz061 crossref_primary_10_3390_ijms22168532 crossref_primary_10_3390_antiox13070756 crossref_primary_10_1038_s41467_022_28385_7 crossref_primary_10_1016_j_foodchem_2021_131647 crossref_primary_10_3390_agronomy15092207 crossref_primary_10_1016_j_drup_2022_100844 crossref_primary_10_1007_s11356_021_12361_7 crossref_primary_10_1016_j_jmb_2019_08_007 crossref_primary_10_3390_foods14183249 crossref_primary_10_1016_j_talanta_2024_126929 crossref_primary_10_3390_antiox8090357 crossref_primary_10_1007_s11427_023_2621_7 crossref_primary_10_1016_j_envres_2018_11_045 crossref_primary_10_1016_j_animal_2022_100459 crossref_primary_10_1016_j_tjnut_2024_10_041 crossref_primary_10_1016_j_jhazmat_2025_138601 crossref_primary_10_1017_S000711452100355X crossref_primary_10_3390_nu12123599 crossref_primary_10_1007_s12011_025_04531_2 crossref_primary_10_3390_ijms222011174 crossref_primary_10_1080_01635581_2022_2115082 crossref_primary_10_1111_1541_4337_70250 crossref_primary_10_3390_ijms232113068 crossref_primary_10_3389_fanim_2023_1165321 crossref_primary_10_1016_j_envint_2020_105626 crossref_primary_10_1002_ncp_10326 crossref_primary_10_1007_s12011_023_03705_0 crossref_primary_10_1016_j_livsci_2022_104856 crossref_primary_10_1002_pros_23752 crossref_primary_10_1016_j_aquaculture_2019_04_006 crossref_primary_10_1016_j_freeradbiomed_2024_05_001 crossref_primary_10_1016_j_compositesb_2023_110984 crossref_primary_10_1016_j_envpol_2017_10_111 crossref_primary_10_1016_j_jtemb_2020_126596 crossref_primary_10_1016_j_psj_2024_103646 crossref_primary_10_1016_j_jtemb_2021_126873 crossref_primary_10_1002_oby_21841 crossref_primary_10_1007_s12011_016_0665_8 crossref_primary_10_1039_D2FO01813F crossref_primary_10_3390_nu14050952 crossref_primary_10_3390_nu14132695 crossref_primary_10_3389_fnut_2021_685317 crossref_primary_10_13005_bpj_2839 crossref_primary_10_1186_s40104_022_00706_2 crossref_primary_10_1017_S0007114523001435 crossref_primary_10_3390_nu13061898 crossref_primary_10_3389_fendo_2021_621687 crossref_primary_10_3390_nu14122410 crossref_primary_10_1073_pnas_2305961120 crossref_primary_10_1039_D1FO00424G crossref_primary_10_3168_jds_2022_22323 crossref_primary_10_3390_ijms222313088 crossref_primary_10_1016_j_chemosphere_2018_09_167 crossref_primary_10_3390_ma16020699 crossref_primary_10_1177_1040638721999368 crossref_primary_10_1016_j_fbio_2025_107318 crossref_primary_10_1016_j_redox_2016_12_025 crossref_primary_10_1016_j_tjnut_2025_01_008 crossref_primary_10_1186_s12885_023_10944_w crossref_primary_10_3390_ijms222111454 crossref_primary_10_1016_j_bbagen_2016_08_015 crossref_primary_10_3390_nu12061894 crossref_primary_10_3945_ajcn_115_110932 crossref_primary_10_1080_1828051X_2021_1894994 crossref_primary_10_3390_nu12061898 crossref_primary_10_1016_j_anifeedsci_2023_115782 crossref_primary_10_1016_j_psj_2023_103347 crossref_primary_10_1016_j_bbrc_2025_152317 crossref_primary_10_1515_revneuro_2019_0057 crossref_primary_10_1016_j_fbio_2020_100875 crossref_primary_10_1016_j_jtemb_2021_126728 crossref_primary_10_3168_jds_2017_13112 crossref_primary_10_1016_j_cell_2019_03_032 crossref_primary_10_1080_10408398_2020_1758027 crossref_primary_10_3390_nu12061769 crossref_primary_10_1016_j_marpolbul_2019_07_017 crossref_primary_10_3389_fnut_2021_683154 crossref_primary_10_3390_antiox14040451 crossref_primary_10_1016_j_scitotenv_2021_150770 crossref_primary_10_1089_ars_2022_0018 crossref_primary_10_21448_ijsm_1553575 crossref_primary_10_1016_j_jtemb_2020_126684 crossref_primary_10_1097_SHK_0000000000001344 crossref_primary_10_2903_j_efsa_2023_7704 crossref_primary_10_3389_fcell_2023_1083904 crossref_primary_10_3390_ani11092711 crossref_primary_10_1017_S000711452100146X crossref_primary_10_1016_j_envpol_2019_113873 crossref_primary_10_1016_j_chemosphere_2020_128007 crossref_primary_10_3390_app10155368 crossref_primary_10_1016_j_jbiotec_2024_09_006 crossref_primary_10_3390_nu13051527 crossref_primary_10_1093_toxres_tfad095 crossref_primary_10_1016_j_envres_2020_110670 crossref_primary_10_1016_j_abb_2022_109400 crossref_primary_10_1007_s12011_023_03674_4 crossref_primary_10_1515_revneuro_2019_0076 crossref_primary_10_1016_j_clnu_2022_02_007 crossref_primary_10_1002_jcp_30175 crossref_primary_10_1016_j_scitotenv_2024_175458 crossref_primary_10_3390_nu14214458 crossref_primary_10_1080_10715762_2025_2516844 crossref_primary_10_1007_s10695_016_0272_9 crossref_primary_10_3390_ani11010238 crossref_primary_10_3389_fnut_2021_685517 crossref_primary_10_3390_molecules21040545 crossref_primary_10_3390_biom13050799 crossref_primary_10_1016_j_bbrc_2025_151879 crossref_primary_10_1038_s41589_022_01033_3 crossref_primary_10_1016_j_tifs_2024_104781 crossref_primary_10_3389_fanim_2022_911094 crossref_primary_10_1007_s13762_023_05169_0 crossref_primary_10_1016_j_freeradbiomed_2024_06_027 crossref_primary_10_1097_MED_0000000000000190 crossref_primary_10_1007_s12011_021_03042_0 crossref_primary_10_3390_nu10050584 crossref_primary_10_1007_s10653_024_02277_9 crossref_primary_10_3390_antiox8080268 crossref_primary_10_1016_j_fbio_2024_103827 crossref_primary_10_3390_nu13093256 crossref_primary_10_1016_j_actpha_2020_03_011 crossref_primary_10_1007_s11274_025_04416_5 crossref_primary_10_1007_s42000_018_0033_5 crossref_primary_10_3390_biology14091295 crossref_primary_10_1016_j_neuro_2023_08_003 crossref_primary_10_1007_s00018_023_05067_1 crossref_primary_10_3390_ijms241210109 crossref_primary_10_1021_acs_est_5c01032 crossref_primary_10_1038_s41598_024_51259_5 crossref_primary_10_1074_jbc_M116_756155 crossref_primary_10_1007_s12011_022_03118_5 crossref_primary_10_1186_s40001_023_01075_w crossref_primary_10_1007_s13668_021_00354_4 crossref_primary_10_3390_antiox13111392 crossref_primary_10_1096_fj_202000856R crossref_primary_10_3389_fnins_2021_631825 crossref_primary_10_3390_ani10050808 crossref_primary_10_1007_s40572_023_00402_x crossref_primary_10_1038_s41467_023_39245_3 crossref_primary_10_1093_nar_gkab498 crossref_primary_10_1002_med_21933 crossref_primary_10_1111_asj_12861 crossref_primary_10_3390_antiox13040391 crossref_primary_10_1007_s12012_024_09910_0 crossref_primary_10_1016_j_burns_2024_107314 crossref_primary_10_1016_j_jtemb_2022_127048 crossref_primary_10_3390_nu14245308 crossref_primary_10_3389_fimmu_2024_1422781 crossref_primary_10_3390_nu11092005 crossref_primary_10_15252_emmm_202318014 crossref_primary_10_1097_IOP_0000000000001136 crossref_primary_10_1002_jcp_30824 crossref_primary_10_1182_blood_2024025402 crossref_primary_10_1146_annurev_nutr_062322_022751 crossref_primary_10_1016_j_trac_2017_11_007 crossref_primary_10_3390_molecules30030437 crossref_primary_10_1016_j_biomaterials_2021_121358 crossref_primary_10_14814_phy2_14933 crossref_primary_10_1007_s12011_023_03963_y crossref_primary_10_3390_ijms25137261 crossref_primary_10_1021_acsbiomaterials_9b01029 crossref_primary_10_1080_1745039X_2019_1641368 crossref_primary_10_1039_C9SC04616J crossref_primary_10_1093_jas_skad041 crossref_primary_10_1007_s12011_021_02731_0 crossref_primary_10_1016_j_biomaterials_2024_123011 crossref_primary_10_1016_j_cdnut_2024_104531 crossref_primary_10_1016_j_jtemb_2022_127031 crossref_primary_10_1007_s00204_021_03003_5 crossref_primary_10_3389_fnut_2023_1127188 crossref_primary_10_1007_s13237_019_00306_y crossref_primary_10_1371_journal_pone_0174880 crossref_primary_10_1017_S0007114523000739 crossref_primary_10_1016_j_lfs_2022_120618 crossref_primary_10_3390_biomedicines9111521 crossref_primary_10_1016_j_retram_2016_10_002 crossref_primary_10_2174_0929867329666220615124412 crossref_primary_10_3389_fnut_2022_917349 crossref_primary_10_3390_biom12081049 crossref_primary_10_3390_ijms242015344 crossref_primary_10_1016_j_freeradbiomed_2018_03_036 crossref_primary_10_1016_j_jtemb_2022_127068 crossref_primary_10_3390_ijms241310887 crossref_primary_10_1016_j_freeradbiomed_2018_02_030 crossref_primary_10_1134_S1995078017030053 crossref_primary_10_1007_s11250_025_04480_x crossref_primary_10_1007_s12011_023_04052_w crossref_primary_10_1186_s12872_024_03825_y crossref_primary_10_1093_mtomcs_mfad066 crossref_primary_10_1186_s40635_019_0281_y crossref_primary_10_1093_mtomcs_mfad067 crossref_primary_10_1007_s11356_022_22108_7 crossref_primary_10_1016_j_jafr_2025_101969 crossref_primary_10_1017_S0954422424000222 crossref_primary_10_1016_j_freeradbiomed_2025_03_044 crossref_primary_10_32604_biocell_2023_025154 crossref_primary_10_1134_S1995078017030065 crossref_primary_10_2903_j_efsa_2019_5539 crossref_primary_10_1007_s00299_024_03197_9 crossref_primary_10_1016_j_jtemb_2018_07_008 crossref_primary_10_3390_antiox10020167 crossref_primary_10_5187_jast_2024_e53 crossref_primary_10_1007_s12011_019_01771_x crossref_primary_10_3390_ijms17071137 crossref_primary_10_3390_antiox8120634 crossref_primary_10_3390_nu9070697 crossref_primary_10_3389_fphar_2022_910292 crossref_primary_10_1016_j_envpol_2025_125942 crossref_primary_10_3390_plants14172622 crossref_primary_10_1080_10408398_2022_2101093 crossref_primary_10_3389_fphys_2022_931386 crossref_primary_10_1016_j_clnesp_2020_10_012 crossref_primary_10_1093_jn_nxz190 crossref_primary_10_1002_ehf2_14893 crossref_primary_10_1016_j_jnutbio_2024_109776 crossref_primary_10_1111_are_15844 crossref_primary_10_3390_antiox11071263 crossref_primary_10_1016_j_jtemb_2020_126660 crossref_primary_10_1016_j_envint_2018_10_018 crossref_primary_10_1016_j_jtemb_2015_10_003 crossref_primary_10_3389_fpls_2022_804368 crossref_primary_10_3390_toxics11090791 crossref_primary_10_1016_j_jhazmat_2023_133380 crossref_primary_10_1017_S000711452100074X crossref_primary_10_1002_adbi_202400383 crossref_primary_10_21676_23897864_4546 crossref_primary_10_3390_nu12072084 crossref_primary_10_3390_biom11101478 crossref_primary_10_1016_j_mad_2019_04_004 crossref_primary_10_3390_ijms232315445 crossref_primary_10_1038_s42255_024_00980_6 crossref_primary_10_3390_antiox13091080 crossref_primary_10_3945_jn_117_247775 crossref_primary_10_3390_nu17142362 crossref_primary_10_1016_j_jtemb_2023_127149 crossref_primary_10_3389_fnut_2022_1062667 crossref_primary_10_1016_j_jinorgbio_2017_01_002 crossref_primary_10_2174_0929867325666180201111159 crossref_primary_10_1007_s12011_025_04516_1 crossref_primary_10_1016_j_envres_2019_108561 crossref_primary_10_1038_s41598_017_04586_9 crossref_primary_10_1073_pnas_2502876122 crossref_primary_10_3390_nu11040935 crossref_primary_10_1021_jacs_1c09525 crossref_primary_10_1111_1541_4337_12748 crossref_primary_10_3168_jds_2023_24283 crossref_primary_10_1093_nar_gkx982 crossref_primary_10_3945_jn_116_247338 crossref_primary_10_3390_antiox8050120 crossref_primary_10_3389_fmicb_2021_723190 crossref_primary_10_1016_j_etap_2024_104430 crossref_primary_10_3382_ps_pey413 crossref_primary_10_1016_j_freeradbiomed_2022_09_019 crossref_primary_10_3389_fendo_2022_1092837 crossref_primary_10_1038_s44321_024_00142_x crossref_primary_10_3390_pharmaceutics12010043 crossref_primary_10_3389_fnut_2024_1449980 crossref_primary_10_1002_adhm_202100598 crossref_primary_10_1002_mnfr_202100644 crossref_primary_10_1016_j_envint_2021_106869 crossref_primary_10_3390_agronomy15061320 crossref_primary_10_3389_fnagi_2021_750921 crossref_primary_10_29219_fnr_v67_10320 crossref_primary_10_1007_s40520_018_1086_7 crossref_primary_10_1016_j_molcel_2024_10_027 crossref_primary_10_3390_toxics11121007 crossref_primary_10_1016_j_jtemb_2019_07_005 crossref_primary_10_1016_j_semcdb_2020_11_006 crossref_primary_10_3389_fnut_2023_1263853 crossref_primary_10_1017_jan_2016_5 crossref_primary_10_3390_ijms17122082 crossref_primary_10_1016_j_snb_2025_137232 crossref_primary_10_3390_antiox13121566 crossref_primary_10_3390_nu10091203 crossref_primary_10_3390_ijms26104924 crossref_primary_10_1016_j_fct_2023_114059 crossref_primary_10_1172_JCI165988 crossref_primary_10_1111_eci_13538 crossref_primary_10_1111_jfb_16036 crossref_primary_10_3390_antiox10040535 crossref_primary_10_1007_s12011_023_03726_9 crossref_primary_10_3390_biomedicines9121871 crossref_primary_10_1016_j_gene_2019_04_015 crossref_primary_10_1007_s12011_022_03275_7 crossref_primary_10_1007_s12011_020_02283_9 crossref_primary_10_1089_ars_2020_8063 crossref_primary_10_1186_s10020_023_00728_0 crossref_primary_10_1089_ars_2020_8062 crossref_primary_10_1111_jnc_15957 crossref_primary_10_1371_journal_pgen_1009716 crossref_primary_10_3390_nu14020283 crossref_primary_10_3390_antiox10071031 crossref_primary_10_1039_D2SC03533B crossref_primary_10_3390_ani12030313 crossref_primary_10_3390_nu14193886 crossref_primary_10_1007_s12011_019_01774_8 crossref_primary_10_2174_0113816128302667240422110226 crossref_primary_10_1007_s12011_022_03453_7 crossref_primary_10_3168_jds_2018_16065 crossref_primary_10_1016_j_trsl_2019_01_004 crossref_primary_10_3389_fnins_2021_630016 crossref_primary_10_3390_molecules28135234 crossref_primary_10_1016_j_aquaculture_2020_735413 crossref_primary_10_1007_s11802_022_4798_4 crossref_primary_10_1007_s40618_016_0559_9 crossref_primary_10_1016_j_envpol_2023_122675 crossref_primary_10_1016_j_nantod_2025_102720 crossref_primary_10_3389_fvets_2020_00591 crossref_primary_10_1017_S0007114523002398 crossref_primary_10_1016_j_jtemb_2020_126709 crossref_primary_10_1089_ars_2020_8044 crossref_primary_10_1139_apnm_2022_0228 crossref_primary_10_1111_jpn_70001 crossref_primary_10_1016_j_freeradbiomed_2022_06_004 crossref_primary_10_1007_s00775_021_01903_6 crossref_primary_10_3390_pharmaceutics13030298 crossref_primary_10_1007_s12011_021_02832_w crossref_primary_10_1080_21678421_2020_1743470 crossref_primary_10_3390_antiox12111973 crossref_primary_10_1016_j_freeradbiomed_2022_08_022 crossref_primary_10_1038_s41598_017_17159_7 crossref_primary_10_1080_1828051X_2025_2457509 crossref_primary_10_1016_j_jare_2025_04_023 crossref_primary_10_3389_fnins_2021_652099 crossref_primary_10_1016_j_ijbiomac_2019_11_221 crossref_primary_10_1021_acs_chemrestox_5c00095 crossref_primary_10_1007_s11356_023_27663_1 crossref_primary_10_1007_s12011_023_03979_4 crossref_primary_10_1002_cac2_12519 crossref_primary_10_1016_j_clnu_2020_02_012 crossref_primary_10_3389_fnut_2021_667587 crossref_primary_10_1002_jsfa_11053 crossref_primary_10_1016_j_tcb_2023_04_005 crossref_primary_10_1210_endocr_bqaa228 crossref_primary_10_1016_j_aquaculture_2021_737819 crossref_primary_10_1016_j_freeradbiomed_2018_02_038 crossref_primary_10_3390_ijms221910646 crossref_primary_10_1016_j_jtemb_2024_127509 crossref_primary_10_1038_s41598_025_11678_4 crossref_primary_10_3945_ajcn_116_131672 crossref_primary_10_1038_s42255_024_00974_4 crossref_primary_10_3390_nu13062085 crossref_primary_10_1007_s12011_019_01784_6 crossref_primary_10_3390_molecules23123053 crossref_primary_10_5187_jast_2023_e62 crossref_primary_10_1002_jpen_2700 crossref_primary_10_1007_s12011_015_0470_9 crossref_primary_10_1080_17474124_2017_1320219 crossref_primary_10_1007_s11270_022_05709_3 crossref_primary_10_3390_nu14173625 crossref_primary_10_3390_horticulturae11091112 crossref_primary_10_1007_s12011_016_0780_6 crossref_primary_10_1093_jn_nxy118 crossref_primary_10_3390_su15076060 crossref_primary_10_3390_su122410693 crossref_primary_10_1016_j_psj_2020_08_061 crossref_primary_10_1038_s41598_025_10581_2 crossref_primary_10_1080_00071668_2020_1782350 crossref_primary_10_3390_antiox11071216 crossref_primary_10_3390_nu11081852 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7U8 7X8 C1K JXQ |
| DOI | 10.1146/annurev-nutr-071714-034250 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management Toxline |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management |
| DatabaseTitleList | TOXLINE MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Diet & Clinical Nutrition |
| EISSN | 1545-4312 |
| EndPage | 134 |
| ExternalDocumentID | 25974694 |
| Genre | Journal Article Review Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIEHS NIH HHS grantid: ES02497 – fundername: NIDDK NIH HHS grantid: DK58763 |
| GroupedDBID | --- -QD -QH .GJ 04C 0R~ 1KX 23M 2QV 36B 39C 3V. 4.4 51A 53G 5FA 5FB 5FC 5FD 5FE 5FF 5FH 5GY 5RE 6PF 70K 70N 70Q 70S 70W 79. 7A. 7B- 7RV 7X2 7X7 85S 88E 88I 8AF 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8NG 8R4 8R5 A8Z AABJL AAGWO AALHT AALUV AAOHI AARJV AAWJP AAWTL AAYIS AAYJJ ABDBF ABDOG ABGRM ABIPL ABJNI ABKGM ABOCM ABUWG ABVYV ABZNY ACAHA ACDVT ACGFS ACGOD ACJYF ACMXS ACQCJ ACRLM ACSOE ACUHS ADANS ADBBV ADEJD ADHEY ADHUB ADLON ADNJN ADOJX ADSVE AEAIQ AEKBM AENEX AEPIK AEUYN AEWIE AFCZG AFERR AFFDN AFKDQ AFKEJ AFKRA AFONB AFRAH AGBCJ AHIXL AHKZM AHMBA AHVNO AI. AICBU AIDEK AIJFW AIZOL AJAAW ALAFQ ALIPV ALMA_UNASSIGNED_HOLDINGS AMTJG AOUBY AQQLW ATAUN ATCPS AZQEC B0M B9D B9E B9F B9G B9H B9L B9N BCFVH BENPR BHPHI BJPMW BKEYQ BKNYI BMSDO BMYRD BPHCQ BVXVI CCPQU CGR CS3 CUY CVF DWQXO DXH E.L EAP EAS EBC EBD EBS ECF ECM ECT ECV EHN EIF EIHBH EJD EMB EMK EMOBN ENC EPT EST ESX EX3 F-Q F-S F-V F-X F-Y F-Z F5P FIWKU FIXEU FMZAJ FQMFW FT0 FU. FUEKT FXG FYUFA GJQJI GLOEX GNDDA GNUQQ GOAVI GQXMV GUQSH H13 HCIFZ HMCUK HZ~ H~9 J1V K9- L7B M0K M0R M1P M22 M2O M2P N9A NAPCQ NEJ NPM O9- OHT P0P P2P PADUT PCD PQQKQ PROAC PSQYO Q2X Q~Q RAR RAV RNS SV3 TUS UBH UKHRP UKR VH1 WH7 WOW WQ9 X7N XOL YSK ZGI ZYWBE ~8M ~KM 7U8 7X8 AAFWJ AAQMF AAXSQ ACKHT ACPHO ACQLW C1K JXQ RIG |
| ID | FETCH-LOGICAL-a441t-675296e6410ea97810d60720bc5d5080e62a15bbeb6906f9953eb6b25bc4af7d2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 501 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000358259600004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| IngestDate | Sat Sep 27 22:49:14 EDT 2025 Wed Feb 19 02:00:41 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | selenocysteine lyase human selenium metabolism apolipoprotein E receptor-2 selenoprotein hierarchy megalin selenoprotein P |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a441t-675296e6410ea97810d60720bc5d5080e62a15bbeb6906f9953eb6b25bc4af7d2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
| PMID | 25974694 |
| PQID | 1697221963 |
| PQPubID | 23479 |
| PageCount | 26 |
| ParticipantIDs | proquest_miscellaneous_1697221963 pubmed_primary_25974694 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-07-17 |
| PublicationDateYYYYMMDD | 2015-07-17 |
| PublicationDate_xml | – month: 07 year: 2015 text: 2015-07-17 day: 17 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Annual review of nutrition |
| PublicationTitleAlternate | Annu Rev Nutr |
| PublicationYear | 2015 |
| SSID | ssj0009333 |
| Score | 2.6266048 |
| SecondaryResourceType | review_article |
| Snippet | Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells utilize it to synthesize the... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 109 |
| SubjectTerms | Animals Biological Availability Biological Transport Biomarkers Diet Dietary Supplements Health Status Homeostasis - physiology Humans Kidney Tubules, Proximal - metabolism LDL-Receptor Related Proteins - physiology Liver - physiology Low Density Lipoprotein Receptor-Related Protein-2 - physiology Nutritional Requirements Organ Specificity Selenium - deficiency Selenium - metabolism Selenium - pharmacokinetics Selenocysteine - metabolism Selenomethionine - metabolism Selenoprotein P - analysis Selenoprotein P - blood Selenoproteins - biosynthesis Selenoproteins - metabolism |
| Title | Regulation of Selenium Metabolism and Transport |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25974694 https://www.proquest.com/docview/1697221963 |
| Volume | 35 |
| WOSCitedRecordID | wos000358259600004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwGA3qfPDFy-Zl3oggvgXTNG2XJxnq8MGV4Y29laRNoLC1c-0E_71f2s75Igi-lLQQCB-nyTlfkvMhdOlII6UShgjfgEAx0OrFVJCEcy1dznhS5SHfHoMw7I3HYtQk3IrmWOVyTqwm6iSPbY782vFFwJjFy83sndiqUXZ3tSmhsY5aLlAZi-pgvHILB7HuNkajPwq7kGxRzu3FncDhxDrgefR3elktM4Od_w5wF203BBP3a0TsoTWdtVGnn4G4nn7iK1wd-axy6W3UvUt1Cd8ac9AJDpfe_B10_VRXqYcXnBv8bJendDHFQ10CbiZpMcUyS_C3Ofo-eh3cv9w-kKa6ApFAgUoCSoEJX_vcoVpa5yua-DRgVMVeAqyNap9Jx1NKK-tlbITwXGgq5qmYSxMk7ABtZHmmjxB2EqEY1Y4WHuM9zpQUCogM93QQxFLxLrpYhiwC9NotCZnpfFFEq6B10WEd92hW22xEzGodX_DjP_Q-QVvAZDxSOV6eopaBf1efoc34o0yL-XkFC3iGo-EX4X_DTg |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+of+Selenium+Metabolism+and+Transport&rft.jtitle=Annual+review+of+nutrition&rft.au=Burk%2C+Raymond+F&rft.au=Hill%2C+Kristina+E&rft.date=2015-07-17&rft.eissn=1545-4312&rft.volume=35&rft.spage=109&rft.epage=134&rft_id=info:doi/10.1146%2Fannurev-nutr-071714-034250&rft.externalDBID=NO_FULL_TEXT |