Homocysteine, B Vitamins, and Cognitive Impairment

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with cognitive decline, white matter damage, brain atrophy, neurofibrillary tangles, and dementia. Most homocysteine-...

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Bibliographic Details
Published in:	Annual review of nutrition Vol. 36; pp. 211 - 239
Main Authors:	Smith, A David, Refsum, Helga
Format:	Journal Article
Language:	English
Published:	United States 17.07.2016
Subjects:	Aging Animals Biomarkers Cerebrovascular Circulation Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - prevention & control Cognitive Dysfunction - epidemiology Cognitive Dysfunction - etiology Cognitive Dysfunction - prevention & control Dietary Supplements - adverse effects Evidence-Based Medicine Folic Acid - adverse effects Folic Acid - metabolism Folic Acid - therapeutic use Homocysteine - blood Homocysteine - metabolism Humans Hyperhomocysteinemia - diet therapy Hyperhomocysteinemia - epidemiology Hyperhomocysteinemia - metabolism Hyperhomocysteinemia - physiopathology Neurodegenerative Diseases - epidemiology Neurodegenerative Diseases - etiology Neurodegenerative Diseases - physiopathology Neurodegenerative Diseases - prevention & control Nootropic Agents - adverse effects Nootropic Agents - metabolism Nootropic Agents - therapeutic use Nutritional Status Practice Guidelines as Topic Risk Factors Vitamin B 12 - adverse effects Vitamin B 12 - metabolism Vitamin B 12 - therapeutic use Vitamin B 6 - adverse effects Vitamin B 6 - metabolism Vitamin B 6 - therapeutic use clinical trial dementia folate cobalamin (vitamin B12) cognition Alzheimer's disease
ISSN:	1545-4312
Online Access:	Get more information
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