Homocysteine, B Vitamins, and Cognitive Impairment
Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with cognitive decline, white matter damage, brain atrophy, neurofibrillary tangles, and dementia. Most homocysteine-...
Uložené v:
| Vydané v: | Annual review of nutrition Ročník 36; s. 211 - 239 |
|---|---|
| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
17.07.2016
|
| Predmet: | |
| ISSN: | 1545-4312 |
| On-line prístup: | Zistit podrobnosti o prístupe |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with cognitive decline, white matter damage, brain atrophy, neurofibrillary tangles, and dementia. Most homocysteine-lowering trials with folate and vitamins B6 and/or B12 tested as protective agents against cognitive decline were poorly designed by including subjects unlikely to benefit during the trial period. In contrast, trials in high-risk subjects, which have taken into account the baseline B vitamin status, show a slowing of cognitive decline and of atrophy in critical brain regions, results that are consistent with modification of the Alzheimer's disease process. Homocysteine may interact with both risk factors and protective factors, thereby identifying people at risk but also providing potential strategies for early intervention. Public health steps to slow cognitive decline should be promoted in individuals who are at risk of dementia, and more trials are needed to see if simple interventions with nutrients can prevent progression to dementia. |
|---|---|
| AbstractList | Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with cognitive decline, white matter damage, brain atrophy, neurofibrillary tangles, and dementia. Most homocysteine-lowering trials with folate and vitamins B6 and/or B12 tested as protective agents against cognitive decline were poorly designed by including subjects unlikely to benefit during the trial period. In contrast, trials in high-risk subjects, which have taken into account the baseline B vitamin status, show a slowing of cognitive decline and of atrophy in critical brain regions, results that are consistent with modification of the Alzheimer's disease process. Homocysteine may interact with both risk factors and protective factors, thereby identifying people at risk but also providing potential strategies for early intervention. Public health steps to slow cognitive decline should be promoted in individuals who are at risk of dementia, and more trials are needed to see if simple interventions with nutrients can prevent progression to dementia. |
| Author | Smith, A David Refsum, Helga |
| Author_xml | – sequence: 1 givenname: A David surname: Smith fullname: Smith, A David email: david.smith@pharm.ox.ac.uk organization: OPTIMA, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom; email: david.smith@pharm.ox.ac.uk – sequence: 2 givenname: Helga surname: Refsum fullname: Refsum, Helga email: david.smith@pharm.ox.ac.uk, helga.refsum@medisin.uio.no organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0316 Oslo, Norway; email: helga.refsum@medisin.uio.no |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27431367$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j01LAzEURYMo9kP_ggyuXDSa95JMMkstagsFN-p2SGYyEmkydZIp9N-rWFcXLofDvTNyGvvoCLkGdgsgyjsT4zi4PY1jHihToEBSJlkl1AmZghSSCg44IbOUPhljFef8nExQ_bS8VFOCqz70zSFl56NbFA_Fu88m-JgWhYltsew_os9-74p12Bk_BBfzBTnrzDa5y2POydvT4-tyRTcvz-vl_YYaISBT3rXaQlOxstXclmiY60DaiiMIK9vOQGPBoVEClbZW4880AC2lqhDRIs7JzZ93N_Rfo0u5Dj41brs10fVjqkEzqcpSi1_06oiONri23g0-mOFQ___EbwBHVqg |
| CitedBy_id | crossref_primary_10_1007_s10072_017_2848_2 crossref_primary_10_1016_j_cmet_2016_08_009 crossref_primary_10_3390_nu12113248 crossref_primary_10_1007_s00394_022_02924_w crossref_primary_10_1016_j_jpba_2019_113033 crossref_primary_10_1007_s43032_021_00704_1 crossref_primary_10_1007_s12603_021_1708_1 crossref_primary_10_3389_fnagi_2020_00140 crossref_primary_10_1016_j_bbi_2021_10_014 crossref_primary_10_3390_nu17182955 crossref_primary_10_1017_S0029665117000404 crossref_primary_10_3233_JAD_201558 crossref_primary_10_1245_s10434_019_07913_8 crossref_primary_10_1182_blood_2016_10_569186 crossref_primary_10_3233_BPL_180071 crossref_primary_10_3389_fnagi_2023_1322419 crossref_primary_10_1007_s11011_019_00482_5 crossref_primary_10_1093_advances_nmy120 crossref_primary_10_3390_ijms22042051 crossref_primary_10_1016_j_lfs_2022_121041 crossref_primary_10_2147_NDT_S333753 crossref_primary_10_1016_j_nupar_2025_04_004 crossref_primary_10_1093_nutrit_nuaf155 crossref_primary_10_1097_WNF_0000000000000594 crossref_primary_10_3233_JAD_210166 crossref_primary_10_1186_s40364_020_00218_z crossref_primary_10_1016_j_biochi_2019_06_017 crossref_primary_10_1289_EHP8036 crossref_primary_10_1038_s41598_024_75760_z crossref_primary_10_3390_ijms22020927 crossref_primary_10_1007_s00429_022_02499_6 crossref_primary_10_1007_s10072_021_05259_2 crossref_primary_10_1093_ajcn_nqab013 crossref_primary_10_1136_bmjopen_2018_026564 crossref_primary_10_1016_j_mam_2016_11_003 crossref_primary_10_3390_nu8120803 crossref_primary_10_3233_JAD_210036 crossref_primary_10_3390_nu16223929 crossref_primary_10_1002_trc2_12159 crossref_primary_10_3233_JAD_171042 crossref_primary_10_3389_fnagi_2024_1361772 crossref_primary_10_3390_ijms20225797 crossref_primary_10_1080_00207454_2020_1860967 crossref_primary_10_1016_j_neurobiolaging_2019_02_001 crossref_primary_10_1016_j_trci_2016_07_002 crossref_primary_10_1038_s41440_022_00999_w crossref_primary_10_3389_fnins_2021_661198 crossref_primary_10_1080_13607863_2021_1875194 crossref_primary_10_1016_j_mayocp_2024_04_016 crossref_primary_10_1016_j_advnut_2024_100184 crossref_primary_10_7554_eLife_93094 crossref_primary_10_1016_j_ajcnut_2024_08_027 crossref_primary_10_1159_000501997 crossref_primary_10_1016_j_parkreldis_2023_105357 crossref_primary_10_1155_2020_8438602 crossref_primary_10_3390_ijms26073060 crossref_primary_10_1007_s12603_020_1489_y crossref_primary_10_1007_s13311_021_01170_y crossref_primary_10_1016_j_neubiorev_2025_106068 crossref_primary_10_1016_j_neurol_2019_08_005 crossref_primary_10_1186_s12877_023_03991_2 crossref_primary_10_1016_j_jnha_2023_100024 crossref_primary_10_1002_alz_12393 crossref_primary_10_1186_s41110_023_00240_9 crossref_primary_10_3390_ijms21103548 crossref_primary_10_3389_fnagi_2018_00049 crossref_primary_10_3390_genes16040441 crossref_primary_10_2147_IJGM_S416230 crossref_primary_10_1007_s12035_023_03329_4 crossref_primary_10_1038_s41430_021_01057_3 crossref_primary_10_1111_hel_12454 crossref_primary_10_1016_j_jamda_2022_05_022 crossref_primary_10_1017_S0029665118000770 crossref_primary_10_1038_s41598_021_92076_4 crossref_primary_10_1016_j_jocn_2020_09_043 crossref_primary_10_1016_j_toxlet_2022_01_019 crossref_primary_10_1177_15333175221146738 crossref_primary_10_1177_03795721241228060 crossref_primary_10_1016_j_jnrt_2025_100187 crossref_primary_10_1089_ars_2021_0204 crossref_primary_10_3389_fnagi_2017_00169 crossref_primary_10_1186_s12916_025_04276_8 crossref_primary_10_1212_WNL_0000000000207656 crossref_primary_10_2147_RMHP_S277521 crossref_primary_10_1093_omcr_omx076 crossref_primary_10_1186_s13148_019_0741_y crossref_primary_10_3389_fcvm_2021_838680 crossref_primary_10_1017_S0029665123002707 crossref_primary_10_1016_j_gerinurse_2025_03_038 crossref_primary_10_3389_fnagi_2021_659402 crossref_primary_10_3390_ijms20020319 crossref_primary_10_1371_journal_pone_0262474 crossref_primary_10_1002_alz_12767 crossref_primary_10_1186_s12964_023_01288_w crossref_primary_10_3390_antiox10060962 crossref_primary_10_1016_j_genhosppsych_2025_01_002 crossref_primary_10_1096_fj_201800346R crossref_primary_10_3390_life13020311 crossref_primary_10_1177_15353702221139209 crossref_primary_10_3233_JAD_215379 crossref_primary_10_1002_hbm_25748 crossref_primary_10_3389_fsurg_2021_813607 crossref_primary_10_3233_JAD_201096 crossref_primary_10_29254_2077_4214_2022_3_166_398_420 crossref_primary_10_1016_j_freeradbiomed_2020_07_036 crossref_primary_10_1111_joim_13279 crossref_primary_10_1080_10408398_2018_1522499 crossref_primary_10_1016_j_phrs_2018_03_012 crossref_primary_10_1016_j_jadr_2025_100947 crossref_primary_10_1089_ars_2021_0269 crossref_primary_10_1111_eci_70045 crossref_primary_10_3390_ani13193056 crossref_primary_10_3390_brainsci9090211 crossref_primary_10_1186_s13561_018_0192_8 crossref_primary_10_1016_j_rbmo_2021_10_024 crossref_primary_10_1210_jc_2018_01791 crossref_primary_10_1016_j_jstrokecerebrovasdis_2020_105537 crossref_primary_10_3390_nu17091407 crossref_primary_10_1016_j_heliyon_2023_e21548 crossref_primary_10_3389_fnut_2019_00110 crossref_primary_10_1016_j_niox_2024_02_001 crossref_primary_10_1186_s13643_020_01378_7 crossref_primary_10_3390_ijms23073582 crossref_primary_10_1080_00207454_2021_1962863 crossref_primary_10_1111_joim_13288 crossref_primary_10_3390_ijms21010062 crossref_primary_10_1111_nbu_12250 crossref_primary_10_3390_nu15081895 crossref_primary_10_1177_15598276241296052 crossref_primary_10_3390_ijms20133140 crossref_primary_10_1038_tp_2017_123 crossref_primary_10_3233_JAD_201537 crossref_primary_10_3389_fnins_2021_778123 crossref_primary_10_1186_s13098_019_0484_0 crossref_primary_10_1007_s12603_022_1809_5 crossref_primary_10_5937_arhfarm2002098Q crossref_primary_10_3233_JAD_210141 crossref_primary_10_1001_jama_2019_4963 crossref_primary_10_1016_j_neurobiolaging_2018_08_028 crossref_primary_10_3233_JAD_210021 crossref_primary_10_1017_S0029665119000661 crossref_primary_10_1002_fsn3_1945 crossref_primary_10_1016_j_trci_2019_11_004 crossref_primary_10_1186_s12974_020_01938_7 crossref_primary_10_1177_03795721241252503 crossref_primary_10_1093_advances_nmab106 crossref_primary_10_1155_2019_6874805 crossref_primary_10_1007_s40495_017_0119_9 crossref_primary_10_3945_ajcn_117_157834 crossref_primary_10_3390_nu14235079 crossref_primary_10_1017_S0029665121000914 crossref_primary_10_1186_s13024_019_0353_1 crossref_primary_10_2174_0113816128280082231205071504 crossref_primary_10_2174_0929867325666180313105949 crossref_primary_10_1007_s00394_021_02774_y crossref_primary_10_3233_JAD_190249 crossref_primary_10_1016_j_nut_2021_111231 crossref_primary_10_3389_fnut_2021_746453 crossref_primary_10_1016_j_cbi_2024_111028 crossref_primary_10_1016_j_jinorgbio_2023_112154 crossref_primary_10_3389_fmed_2022_864152 crossref_primary_10_1038_srep46002 crossref_primary_10_3233_JAD_230641 crossref_primary_10_1259_bjr_20220415 crossref_primary_10_1016_j_neuint_2017_12_003 crossref_primary_10_3389_fneur_2022_890499 crossref_primary_10_3164_jcbn_24_233 crossref_primary_10_1016_j_jocn_2021_09_033 crossref_primary_10_1007_s11920_022_01355_y crossref_primary_10_1016_j_exger_2018_07_006 crossref_primary_10_14283_jarlife_2023_7 crossref_primary_10_7554_eLife_93094_3 crossref_primary_10_1017_S0029665117004177 crossref_primary_10_1016_j_jad_2022_01_013 crossref_primary_10_1136_jnnp_2019_322366 crossref_primary_10_1002_mnfr_201700461 crossref_primary_10_1007_s00394_017_1598_5 crossref_primary_10_1007_s12035_024_03995_y crossref_primary_10_1016_j_cophys_2019_04_024 crossref_primary_10_1016_j_tjpad_2025_100265 crossref_primary_10_1002_trc2_12202 crossref_primary_10_1016_j_neubiorev_2023_105035 crossref_primary_10_3390_nu8110725 crossref_primary_10_1016_j_heliyon_2023_e22903 crossref_primary_10_1146_annurev_animal_020518_115206 crossref_primary_10_3390_nu15010132 crossref_primary_10_1007_s12640_021_00429_8 crossref_primary_10_3390_nu15163501 crossref_primary_10_1007_s11357_025_01567_z crossref_primary_10_3233_JAD_200997 crossref_primary_10_1016_j_rasd_2024_102410 crossref_primary_10_3390_nu8120761 crossref_primary_10_1016_j_neulet_2022_136826 crossref_primary_10_1007_s12291_024_01205_z crossref_primary_10_1007_s12603_022_1810_z crossref_primary_10_1016_j_jksus_2023_102820 crossref_primary_10_3389_fneur_2024_1434210 crossref_primary_10_1177_0260106016686094 crossref_primary_10_1016_j_mehy_2022_110808 crossref_primary_10_3390_nu13030923 crossref_primary_10_3390_nu14122443 crossref_primary_10_3390_antiox9040346 crossref_primary_10_3390_nu15051243 crossref_primary_10_1016_j_dsx_2023_102883 crossref_primary_10_3233_JAD_161081 crossref_primary_10_1080_15257770_2024_2313573 crossref_primary_10_1111_acel_12689 crossref_primary_10_1017_S0007114518002945 crossref_primary_10_1093_nutrit_nuab057 crossref_primary_10_3390_nu8120777 crossref_primary_10_1007_s40266_019_00649_w crossref_primary_10_3233_RNN_201053 crossref_primary_10_3389_fnut_2023_1179807 crossref_primary_10_1002_acn3_50838 crossref_primary_10_1177_0891988720988910 crossref_primary_10_1016_j_neubiorev_2018_10_022 crossref_primary_10_1038_s41380_018_0062_0 crossref_primary_10_1177_09564624231218762 crossref_primary_10_1016_j_neuint_2022_105401 crossref_primary_10_3233_JAD_230710 crossref_primary_10_3390_nu14071412 crossref_primary_10_3389_fnagi_2021_707958 crossref_primary_10_1111_jhn_12566 crossref_primary_10_1007_s12035_018_1128_3 crossref_primary_10_1016_j_ajcnut_2023_01_005 crossref_primary_10_1097_MD_0000000000023829 crossref_primary_10_3945_an_117_015610 crossref_primary_10_1017_S0007114520000951 crossref_primary_10_1097_CM9_0000000000002062 crossref_primary_10_1007_s00415_022_11361_y crossref_primary_10_1016_j_ajcnut_2025_05_029 crossref_primary_10_1016_j_clnesp_2021_12_013 crossref_primary_10_1093_ageing_afae032 crossref_primary_10_3390_nu14173535 crossref_primary_10_3389_fnagi_2022_931560 crossref_primary_10_1080_20473869_2024_2410534 crossref_primary_10_1093_jn_nxaa111 crossref_primary_10_3390_nu13113979 crossref_primary_10_1177_13872877251379700 crossref_primary_10_1038_s41598_022_23136_6 crossref_primary_10_1007_s11062_020_09832_x crossref_primary_10_3233_JAD_201481 crossref_primary_10_1080_10715762_2016_1271122 crossref_primary_10_3390_ijms20010231 crossref_primary_10_1016_j_redox_2025_103668 crossref_primary_10_3389_fnagi_2018_00350 crossref_primary_10_1016_j_smrv_2018_08_001 crossref_primary_10_3390_medicina58081025 crossref_primary_10_3233_JAD_220685 crossref_primary_10_1186_s12906_023_03940_x crossref_primary_10_1016_j_jchromb_2019_06_005 crossref_primary_10_2147_NDT_S393624 crossref_primary_10_1017_S0029665117001938 crossref_primary_10_1093_gerona_glae114 crossref_primary_10_3233_JAD_181148 crossref_primary_10_1016_j_arr_2024_102210 crossref_primary_10_1080_10408363_2021_1885339 crossref_primary_10_3389_fnagi_2022_868777 crossref_primary_10_1155_2022_2156483 crossref_primary_10_1007_s00394_021_02607_y crossref_primary_10_1016_j_arr_2019_02_006 crossref_primary_10_1177_13872877251350297 crossref_primary_10_1016_j_jstrokecerebrovasdis_2020_105109 crossref_primary_10_1017_S0029665117000040 crossref_primary_10_1093_hmg_ddab246 crossref_primary_10_1684_epd_2018_1017 crossref_primary_10_3389_fneur_2021_665075 crossref_primary_10_1016_j_mad_2024_111961 crossref_primary_10_1016_j_neuroscience_2025_06_018 crossref_primary_10_3389_fnagi_2021_665114 crossref_primary_10_1007_s44411_025_00184_8 crossref_primary_10_3390_nu15183891 crossref_primary_10_1016_j_clnu_2023_10_025 crossref_primary_10_3389_fcell_2024_1322844 crossref_primary_10_1016_j_arr_2020_101079 crossref_primary_10_1016_j_clnu_2022_06_035 crossref_primary_10_1016_j_neuroscience_2025_07_046 crossref_primary_10_3390_nu11081951 crossref_primary_10_2147_NDT_S387063 crossref_primary_10_1080_1028415X_2024_2375171 crossref_primary_10_14283_jarlife_2020_10 crossref_primary_10_3389_fnut_2022_823573 crossref_primary_10_1007_s12035_023_03377_w crossref_primary_10_3390_antiox6040076 crossref_primary_10_2147_NDT_S337617 crossref_primary_10_1080_00207454_2022_2158825 crossref_primary_10_1016_j_jad_2020_08_022 crossref_primary_10_3390_biom11101546 crossref_primary_10_3390_brainsci10090637 crossref_primary_10_3390_nu13020362 crossref_primary_10_3233_JAD_180032 crossref_primary_10_1007_s12603_017_0989_x crossref_primary_10_3389_fpsyt_2024_1340138 crossref_primary_10_3390_jcm13247541 crossref_primary_10_1093_arclin_acae091 crossref_primary_10_1186_s12986_025_00981_6 crossref_primary_10_3390_nu13092966 crossref_primary_10_1007_s12035_022_02871_x crossref_primary_10_1074_jbc_RA120_016069 crossref_primary_10_1136_jclinpath_2018_205048 crossref_primary_10_3233_JAD_181007 crossref_primary_10_1186_s12902_019_0402_3 crossref_primary_10_1007_s12603_017_0893_4 crossref_primary_10_1007_s00394_023_03130_y crossref_primary_10_1186_s12263_018_0611_9 crossref_primary_10_1007_s12031_024_02236_0 crossref_primary_10_1093_hmg_ddx088 crossref_primary_10_1213_ANE_0000000000004490 crossref_primary_10_1016_j_tjnut_2023_10_012 crossref_primary_10_3389_fneur_2019_00807 crossref_primary_10_3389_fphys_2018_01359 crossref_primary_10_1002_gps_5458 crossref_primary_10_1016_j_neuint_2021_105143 crossref_primary_10_3945_ajcn_116_146365 crossref_primary_10_1111_psyg_70071 crossref_primary_10_1186_s12883_017_0990_3 crossref_primary_10_3389_fnut_2024_1285502 crossref_primary_10_3390_inorganics12090248 crossref_primary_10_1016_j_nutres_2022_10_008 crossref_primary_10_3389_fnut_2022_1042425 crossref_primary_10_1139_cjpp_2020_0507 crossref_primary_10_1038_s41598_017_05205_3 crossref_primary_10_3389_fcvm_2024_1419579 crossref_primary_10_1080_1028415X_2017_1385176 crossref_primary_10_3389_fcell_2019_00183 crossref_primary_10_3390_ijms24021659 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7U8 7X8 C1K JXQ |
| DOI | 10.1146/annurev-nutr-071715-050947 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management Toxline |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management |
| DatabaseTitleList | TOXLINE MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Diet & Clinical Nutrition |
| EISSN | 1545-4312 |
| EndPage | 239 |
| ExternalDocumentID | 27431367 |
| Genre | Journal Article Review |
| GroupedDBID | --- -QD -QH 04C 0R~ 1KX 36B 39C 4.4 51A 5FA 5FB 5FC 5FD 5FE 5FF 5GY 5RE 6PF 7A. 85S 8NG AABJL AAFWJ AAGWO AALHT AALUV AAOHI AAQMF AARJV AAWJP AAWTL AAXSQ AAYIS ABDOG ABGRM ABIPL ABJNI ABKGM ABOCM ABZNY ACAHA ACDVT ACGFS ACGOD ACJYF ACKHT ACMXS ACPHO ACQCJ ACQLW ACRLM ACSOE ADEJD ADHEY ADHUB ADLON ADNJN ADOJX ADSVE AEAIQ AEKBM AENEX AEPIK AFCZG AFERR AFKDQ AFKEJ AFONB AFRAH AGBCJ AHIXL AHKZM AHMBA AHVNO AIDEK AIJFW AIZOL AJAAW ALAFQ ALIPV ALMA_UNASSIGNED_HOLDINGS AMTJG AQQLW B9D B9E B9F B9G B9H B9L B9N BCFVH BJPMW BMYRD CGR CS3 CUY CVF E.L EBS ECM EIF EJD EMB EST F-Q F-S F-V F-X F-Y F-Z F5P FIWKU FIXEU FMZAJ FQMFW FT0 FU. FUEKT FXG GJQJI GLOEX GNDDA GOAVI GQXMV H13 HZ~ J1V L7B M22 N9A NEJ NPM O9- P0P P2P RAR RAV UBH WH7 YSK ZYWBE ~KM 7U8 7X8 A8Z C1K JXQ RIG TUS |
| ID | FETCH-LOGICAL-a441t-3fd8b1c906d83b62a0ef15b93214b5dfa1cb1e2a74278bb823331185579222b22 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 384 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000381633900010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| IngestDate | Wed Oct 01 14:20:57 EDT 2025 Mon Jul 21 06:05:13 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | clinical trial dementia folate cobalamin (vitamin B12) cognition Alzheimer's disease |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a441t-3fd8b1c906d83b62a0ef15b93214b5dfa1cb1e2a74278bb823331185579222b22 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| PMID | 27431367 |
| PQID | 1805766842 |
| PQPubID | 23479 |
| PageCount | 29 |
| ParticipantIDs | proquest_miscellaneous_1805766842 pubmed_primary_27431367 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-07-17 |
| PublicationDateYYYYMMDD | 2016-07-17 |
| PublicationDate_xml | – month: 07 year: 2016 text: 2016-07-17 day: 17 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Annual review of nutrition |
| PublicationTitleAlternate | Annu Rev Nutr |
| PublicationYear | 2016 |
| SSID | ssj0009333 |
| Score | 2.6304152 |
| SecondaryResourceType | review_article |
| Snippet | Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, elevated... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 211 |
| SubjectTerms | Aging Animals Biomarkers Cerebrovascular Circulation Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - prevention & control Cognitive Dysfunction - epidemiology Cognitive Dysfunction - etiology Cognitive Dysfunction - prevention & control Dietary Supplements - adverse effects Evidence-Based Medicine Folic Acid - adverse effects Folic Acid - metabolism Folic Acid - therapeutic use Homocysteine - blood Homocysteine - metabolism Humans Hyperhomocysteinemia - diet therapy Hyperhomocysteinemia - epidemiology Hyperhomocysteinemia - metabolism Hyperhomocysteinemia - physiopathology Neurodegenerative Diseases - epidemiology Neurodegenerative Diseases - etiology Neurodegenerative Diseases - physiopathology Neurodegenerative Diseases - prevention & control Nootropic Agents - adverse effects Nootropic Agents - metabolism Nootropic Agents - therapeutic use Nutritional Status Practice Guidelines as Topic Risk Factors Vitamin B 12 - adverse effects Vitamin B 12 - metabolism Vitamin B 12 - therapeutic use Vitamin B 6 - adverse effects Vitamin B 6 - metabolism Vitamin B 6 - therapeutic use |
| Title | Homocysteine, B Vitamins, and Cognitive Impairment |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27431367 https://www.proquest.com/docview/1805766842 |
| Volume | 36 |
| WOSCitedRecordID | wos000381633900010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NS8MwFA_qPHjxY_NjfhFBPC24pk3TnmROxzxYdlDZrSRpCgWXzrUT_O996VrmRRC89FAItI-Xl9_7yO-H0LUKuEg8JklIhUfgvGZEeqkgnhJ9TzEmqZaV2ASPomA6DSd1wa2oxyqbmFgF6iRXtkZ-6wSALHzbNbqbfxCrGmW7q7WExiZquQBlrFfz6ZotHJJ1tyYa_SHsQsyyXNiLO9xhxNKfePx3eFkdM6O9_37gPtqtASYerDziAG1o00adgYHkevaFb3A18lnV0tuo-5DpEt7V5KDvOGq4-TuIjvNZrizPM-DQHr7Hb1kpZpkpeliYBA-bsSP8BAElW9gi4yF6HT2-DMekFlggAlBQSdw0CaSjwr6fBK70qejr1GEytOJFkiWpcJR0NBXc6nFIGVCwJyQkjPEQYIWk9AhtmdzoE4SZkvDvkrtMQM7lhLBUu30lA8aVC5u8i64aq8XgwLYrIYzOl0W8tlsXHa9MH89XTBsxtfjG9fnpH1afoR0AMz6pSC_PUSuF7asv0Lb6LLNicVl5BjyjyfM3kZXDXA |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Homocysteine%2C+B+Vitamins%2C+and+Cognitive+Impairment&rft.jtitle=Annual+review+of+nutrition&rft.au=Smith%2C+A+David&rft.au=Refsum%2C+Helga&rft.date=2016-07-17&rft.eissn=1545-4312&rft.volume=36&rft.spage=211&rft.epage=239&rft_id=info:doi/10.1146%2Fannurev-nutr-071715-050947&rft.externalDBID=NO_FULL_TEXT |