Optimized and Robust Workflow for Quantifying the Canonical Histone Ubiquitination Marks H2AK119ub and H2BK120ub by LC-MS/MS

The eukaryotic genome is packaged around histone proteins, which are subject to a myriad of post-translational modifications. By controlling DNA accessibility and the recruitment of protein complexes that mediate chromatin-related processes, these modifications constitute a key mechanism of epigenet...

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Bibliographic Details
Published in:	Journal of proteome research Vol. 23; no. 12; p. 5405
Main Authors:	Lopes, Mariana, Lund, Peder J, Garcia, Benjamin A
Format:	Journal Article
Language:	English
Published:	United States 06.12.2024
Subjects:	Anhydrides Chromatography, Liquid - methods Histone Code Histones - metabolism Humans Liquid Chromatography-Mass Spectrometry Propionates Protein Processing, Post-Translational Proteomics - methods Tandem Mass Spectrometry - methods Ubiquitination Workflow histones post-translational modifications ubiquitination LC−MS/MS epigenetics
ISSN:	1535-3907, 1535-3907
Online Access:	Get more information
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