Next-Generation Lipids in RNA Interference Therapeutics

RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (...

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Vydané v:	ACS nano Ročník 11; číslo 8; s. 7572 - 7586
Hlavní autori:	Rietwyk, Stephanie, Peer, Dan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Chemical Society 22.08.2017
Predmet:	Animals Cations - chemistry Gene Silencing - physiology Humans Lipids - chemistry Nanoparticles - chemistry RNA Interference - physiology RNA, Small Interfering - genetics RNA, Small Interfering - physiology toxicity RNAi therapeutics lipidoids delivery lipid nanoparticles RNA interference cationic lipids ionizable amino lipids gene silencing siRNA
ISSN:	1936-0851, 1936-086X, 1936-086X
On-line prístup:	Získať plný text
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