Next-Generation Lipids in RNA Interference Therapeutics

RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (...

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Bibliographic Details
Published in:	ACS nano Vol. 11; no. 8; pp. 7572 - 7586
Main Authors:	Rietwyk, Stephanie, Peer, Dan
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 22.08.2017
Subjects:	Animals Cations - chemistry Gene Silencing - physiology Humans Lipids - chemistry Nanoparticles - chemistry RNA Interference - physiology RNA, Small Interfering - genetics RNA, Small Interfering - physiology toxicity RNAi therapeutics lipidoids delivery lipid nanoparticles RNA interference cationic lipids ionizable amino lipids gene silencing siRNA
ISSN:	1936-0851, 1936-086X, 1936-086X
Online Access:	Get full text
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