Next-Generation Lipids in RNA Interference Therapeutics

RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	ACS nano Ročník 11; číslo 8; s. 7572 - 7586
Hlavní autoři:	Rietwyk, Stephanie, Peer, Dan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Chemical Society 22.08.2017
Témata:	Animals Cations - chemistry Gene Silencing - physiology Humans Lipids - chemistry Nanoparticles - chemistry RNA Interference - physiology RNA, Small Interfering - genetics RNA, Small Interfering - physiology toxicity RNAi therapeutics lipidoids delivery lipid nanoparticles RNA interference cationic lipids ionizable amino lipids gene silencing siRNA
ISSN:	1936-0851, 1936-086X, 1936-086X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (LNPs) are the most advanced platform among nonviral vectors for gene delivery. In this review, we critically review the literature and the reasons for ineffective delivery beyond the liver. We discuss the toxicity issues associated with permanently charged cationic lipids and then turn our attention to next-generation ionizable cationic lipids. These lipids exhibit reduced toxicity and immunogenicity and undergo ionization under the acidic environment of the endosome to release the encapsulated payload to their site of action in the cytosol. Finally, we summarize recent achievements in therapeutic nucleic acid delivery and report on the current status of clinical trials using LNP and the obstacles to clinical translation.
AbstractList	RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (LNPs) are the most advanced platform among nonviral vectors for gene delivery. In this review, we critically review the literature and the reasons for ineffective delivery beyond the liver. We discuss the toxicity issues associated with permanently charged cationic lipids and then turn our attention to next-generation ionizable cationic lipids. These lipids exhibit reduced toxicity and immunogenicity and undergo ionization under the acidic environment of the endosome to release the encapsulated payload to their site of action in the cytosol. Finally, we summarize recent achievements in therapeutic nucleic acid delivery and report on the current status of clinical trials using LNP and the obstacles to clinical translation. RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (LNPs) are the most advanced platform among nonviral vectors for gene delivery. In this review, we critically review the literature and the reasons for ineffective delivery beyond the liver. We discuss the toxicity issues associated with permanently charged cationic lipids and then turn our attention to next-generation ionizable cationic lipids. These lipids exhibit reduced toxicity and immunogenicity and undergo ionization under the acidic environment of the endosome to release the encapsulated payload to their site of action in the cytosol. Finally, we summarize recent achievements in therapeutic nucleic acid delivery and report on the current status of clinical trials using LNP and the obstacles to clinical translation.RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (LNPs) are the most advanced platform among nonviral vectors for gene delivery. In this review, we critically review the literature and the reasons for ineffective delivery beyond the liver. We discuss the toxicity issues associated with permanently charged cationic lipids and then turn our attention to next-generation ionizable cationic lipids. These lipids exhibit reduced toxicity and immunogenicity and undergo ionization under the acidic environment of the endosome to release the encapsulated payload to their site of action in the cytosol. Finally, we summarize recent achievements in therapeutic nucleic acid delivery and report on the current status of clinical trials using LNP and the obstacles to clinical translation.
Author	Rietwyk, Stephanie Peer, Dan
AuthorAffiliation	Laboratory of Precision NanoMedicine, Department of Cell Research & Immunology, George S. Wise Faculty of Life Sciences Cancer Biology Research Center Tel Aviv University Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering Center for Nanoscience and Nanotechnology
AuthorAffiliation_xml	– name: Laboratory of Precision NanoMedicine, Department of Cell Research & Immunology, George S. Wise Faculty of Life Sciences – name: Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering – name: Center for Nanoscience and Nanotechnology – name: Tel Aviv University – name: Cancer Biology Research Center
Author_xml	– sequence: 1 givenname: Stephanie surname: Rietwyk fullname: Rietwyk, Stephanie – sequence: 2 givenname: Dan orcidid: 0000-0003-4408-8350 surname: Peer fullname: Peer, Dan email: peer@tauex.tau.ac.il
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28727419$$D View this record in MEDLINE/PubMed
BookMark	eNp1kMFLwzAUh4NMnJuevUmPgnRL0jZpjmPoHIwJMsFbSNMXzOjSmbSg_73VdR6End6D9_1-8L4RGrjaAUI3BE8IpmSqdHDK1RNe4JQn6Rm6JCJhMc7Z2-Bvz8gQjULYYpzxnLMLNKQ5pzwl4hLxNXw28QIceNXY2kUru7dliKyLXtazaOka8AY8OA3R5r2D9tA2VocrdG5UFeC6n2P0-viwmT_Fq-fFcj5bxSpNcRPnmS6FKTNqciYUY8JowzTnhGpRJsAMAZYQboqCFKlWLMWGphyXAmuqMc6TMbo79O59_dFCaOTOBg1VpRzUbZBEUJrhRHDSobc92hY7KOXe253yX_L4bAdkB0D7OgQPRmrb_H7deGUrSbD8kSp7qbKX2uWm_3LH6tOJ-0OiO8ht3XrXOTpJfwOTrYj8
CitedBy_id	crossref_primary_10_1002_smll_202505404 crossref_primary_10_1016_j_addr_2020_04_002 crossref_primary_10_1080_17425247_2024_2409142 crossref_primary_10_1016_j_ijpx_2024_100283 crossref_primary_10_1038_s41467_018_06936_1 crossref_primary_10_1016_j_ymthe_2018_07_010 crossref_primary_10_1016_j_cclet_2024_109724 crossref_primary_10_1016_j_ijpharm_2022_121596 crossref_primary_10_1016_j_biomaterials_2022_121510 crossref_primary_10_1016_j_ymthe_2021_03_015 crossref_primary_10_1088_1361_6528_aa98e3 crossref_primary_10_1080_17425247_2025_2466767 crossref_primary_10_1016_j_omtn_2019_12_004 crossref_primary_10_1002_smll_202312153 crossref_primary_10_1016_j_actbio_2019_11_022 crossref_primary_10_1124_jpet_119_256909 crossref_primary_10_3390_nano12122072 crossref_primary_10_1016_j_addr_2022_114417 crossref_primary_10_1097_SHK_0000000000002450 crossref_primary_10_1016_j_chemphyslip_2020_105032 crossref_primary_10_3390_pharmaceutics15010153 crossref_primary_10_1038_s41467_019_12275_6 crossref_primary_10_1039_C9RA03608C crossref_primary_10_1002_bmm2_12018 crossref_primary_10_3390_pharmaceutics15082068 crossref_primary_10_1016_j_dmpk_2022_100450 crossref_primary_10_1016_j_nano_2023_102711 crossref_primary_10_1002_adtp_201800085 crossref_primary_10_1002_adma_202305300 crossref_primary_10_1002_adhm_202500646 crossref_primary_10_1016_j_cis_2019_03_007 crossref_primary_10_3390_molecules28176328 crossref_primary_10_3389_fphar_2022_984981 crossref_primary_10_1002_bit_28200 crossref_primary_10_1002_smll_202407040 crossref_primary_10_1002_btm2_10213 crossref_primary_10_3390_ph15081017 crossref_primary_10_3390_pharmaceutics17080992 crossref_primary_10_1016_j_jconrel_2020_04_003 crossref_primary_10_1016_j_actbio_2021_06_020 crossref_primary_10_3103_S0027131419060087 crossref_primary_10_1016_j_nantod_2022_101403 crossref_primary_10_1039_C9BM00494G crossref_primary_10_1016_j_actbio_2024_02_004 crossref_primary_10_1016_j_colsurfb_2022_112651 crossref_primary_10_1080_08982104_2023_2187821 crossref_primary_10_1039_C9NR05475H crossref_primary_10_1016_j_addr_2021_114041 crossref_primary_10_1073_pnas_2301067120 crossref_primary_10_1073_pnas_2307813120 crossref_primary_10_3390_pharmaceutics13071063 crossref_primary_10_1002_adtp_202100108 crossref_primary_10_3390_pharmaceutics11090431 crossref_primary_10_1016_j_biopha_2021_111953 crossref_primary_10_1016_j_ijpharm_2024_124779 crossref_primary_10_3390_nano8050270 crossref_primary_10_1002_adfm_202203669 crossref_primary_10_1016_j_addr_2022_114236 crossref_primary_10_1016_j_apmt_2021_101201 crossref_primary_10_1002_adfm_202101391 crossref_primary_10_1016_j_biotechadv_2024_108395 crossref_primary_10_3389_fphar_2018_00307 crossref_primary_10_1016_j_actbio_2022_09_065 crossref_primary_10_1002_adhm_202203033 crossref_primary_10_3390_cancers13195002 crossref_primary_10_1016_j_biomaterials_2018_08_042 crossref_primary_10_1049_nbt2_12028 crossref_primary_10_1016_j_actbio_2022_09_016 crossref_primary_10_1016_j_jconrel_2022_08_009 crossref_primary_10_1016_j_nantod_2019_100766 crossref_primary_10_1002_smll_201704039 crossref_primary_10_1016_j_actbio_2022_04_033 crossref_primary_10_3390_life9030059 crossref_primary_10_1080_15476286_2018_1454812 crossref_primary_10_3390_vaccines9091033 crossref_primary_10_1016_j_jconrel_2019_01_006 crossref_primary_10_3390_ph16071007 crossref_primary_10_1002_adfm_202011103 crossref_primary_10_1002_adtp_202000203 crossref_primary_10_1002_adhm_202001594 crossref_primary_10_3390_pharmaceutics17010025 crossref_primary_10_1016_j_biomaterials_2019_119742 crossref_primary_10_1016_j_mattod_2025_07_028 crossref_primary_10_1002_adma_201906128 crossref_primary_10_1111_raq_12916 crossref_primary_10_1016_j_ijpharm_2021_120851 crossref_primary_10_3390_ijms21113956 crossref_primary_10_1002_adma_202201095 crossref_primary_10_1002_anbr_202200168 crossref_primary_10_3389_fbioe_2022_882363 crossref_primary_10_1002_adtp_202000159 crossref_primary_10_1136_thoraxjnl_2019_213037 crossref_primary_10_1038_s41598_019_53462_1 crossref_primary_10_2147_IJN_S298606 crossref_primary_10_1016_j_jddst_2025_107458 crossref_primary_10_1007_s11060_018_2966_6 crossref_primary_10_1007_s11095_022_03460_2 crossref_primary_10_1016_j_jconrel_2020_03_006 crossref_primary_10_1016_j_ijpharm_2020_120122 crossref_primary_10_1134_S0006297921070026 crossref_primary_10_1016_j_jconrel_2022_06_017 crossref_primary_10_1016_j_nano_2017_12_026 crossref_primary_10_1038_s41573_019_0017_4 crossref_primary_10_1002_jgm_3041 crossref_primary_10_1016_j_actbio_2018_12_041 crossref_primary_10_1039_D0BM01335H crossref_primary_10_1016_j_chempr_2023_03_018 crossref_primary_10_1089_nat_2018_0762 crossref_primary_10_1002_adhm_201900500 crossref_primary_10_3390_ijms21093253 crossref_primary_10_1016_j_biotechadv_2024_108342 crossref_primary_10_1016_j_jddst_2024_105664 crossref_primary_10_1038_s41467_024_45666_5 crossref_primary_10_3390_pharmaceutics14040821 crossref_primary_10_1038_s44222_025_00314_5 crossref_primary_10_1039_C9NR08958F crossref_primary_10_3390_vaccines9040310 crossref_primary_10_1007_s12274_020_3216_8 crossref_primary_10_1002_smll_202305923 crossref_primary_10_1016_j_ejpb_2019_02_012 crossref_primary_10_1016_j_bbrc_2025_152226 crossref_primary_10_1016_j_addr_2024_115446 crossref_primary_10_1021_acsnano_4c18274 crossref_primary_10_3390_pharmaceutics15020656 crossref_primary_10_1016_j_bioadv_2022_212984 crossref_primary_10_1016_j_jsps_2023_05_017 crossref_primary_10_1016_j_addr_2021_05_018 crossref_primary_10_1016_j_jconrel_2020_11_009
Cites_doi	10.1021/bi00152a045 10.1038/mtna.2012.28 10.1016/0005-2736(94)90231-3 10.1016/S0021-9258(17)41980-6 10.1038/nnano.2007.387 10.4049/jimmunol.146.12.4234 10.1126/science.7684856 10.1371/journal.pone.0133154 10.1038/nnano.2012.168 10.1016/S0014-5793(96)01397-X 10.1038/mtna.2016.40 10.1016/0169-409X(95)00020-8 10.1073/pnas.84.21.7413 10.1021/bc300346h 10.1016/j.jacc.2013.11.023 10.1016/j.ajps.2014.08.011 10.1021/acs.nanolett.5b01362 10.1016/j.ijpharm.2017.01.016 10.1021/nn506248s 10.1073/pnas.0707461104 10.1126/scitranslmed.aaf1435 10.1016/j.addr.2004.12.004 10.1038/nmat3765 10.1186/1758-907X-1-14 10.1016/j.jconrel.2005.06.014 10.1074/jbc.270.32.18997 10.1038/nbt.2614 10.1021/acsnano.5b02796 10.1038/mtna.2016.68 10.1016/S0168-3659(99)00158-3 10.1038/mt.2016.179 10.1073/pnas.1619653114 10.1038/mt.2013.124 10.1038/sj.gt.3301506 10.1016/S0005-2736(01)00399-6 10.1016/S0021-9258(17)46228-4 10.1161/CIRCULATIONAHA.112.000116 10.1073/pnas.1306529110 10.1073/pnas.93.21.11493 10.1016/j.jconrel.2006.04.014 10.1002/anie.201203263 10.1016/j.jconrel.2013.09.013 10.1038/nbt.2612 10.1089/hum.1992.3.3-267 10.1038/nature04688 10.1016/j.abb.2004.12.010 10.1073/pnas.94.4.1160 10.1016/j.biomaterials.2010.05.027 10.1038/nbt.1602 10.1016/S0005-2736(00)00226-1 10.1016/S0005-2736(96)00241-6 10.1073/pnas.1519273113 10.1016/S0005-2736(00)00343-6 10.1111/j.1749-6632.1994.tb21701.x 10.1007/s11745-005-1446-5 10.1038/mtna.2011.3 10.3109/08982109709035481 10.1126/science.1149859 10.1038/nbt1081 10.1039/f29767201525 10.1021/la201464k 10.1021/bi971772j 10.1021/mp800049w 10.1016/S0005-2736(98)00002-9 10.1016/j.bmcl.2005.04.010 10.1016/0005-2736(92)90316-E 10.1038/nbt.1989 10.1016/S0026-895X(25)09229-6 10.1021/mp400467x 10.1023/A:1018932714745 10.1038/nrd2310 10.1016/j.jconrel.2012.12.014 10.1038/nbt.2634 10.1021/jm000006z 10.1016/j.ejpb.2008.06.026 10.1158/0008-5472.CAN-05-4199 10.1021/jm010918g 10.1038/nbt1122 10.1016/j.addr.2012.06.013 10.1038/sj.gt.3301471 10.1038/mt.2010.85 10.1038/ncomms5277 10.1517/17425247.2012.642363 10.1021/jp303267y 10.1016/j.biomaterials.2008.04.036 10.1021/ja301621z 10.1021/acs.jpcb.5b02891 10.1002/(SICI)1521-2254(199903/04)1:2<111::AID-JGM22>3.3.CO;2-P 10.1177/1535370216640944 10.1016/j.nano.2012.05.019 10.1016/j.ymthe.2004.12.018 10.1038/nbt1402 10.1007/s12195-016-0436-9 10.1038/mt.2009.271 10.1016/0024-3205(91)90480-Y 10.1038/nature03121 10.1038/mt.2009.208 10.3109/10611869509059214 10.1038/mt.2011.56 10.1016/j.jconrel.2006.06.024 10.1039/b609510k 10.1016/0006-291X(92)90565-3 10.1038/nrd4685 10.1002/chem.200305232 10.1152/ajpheart.1997.273.1.H387 10.1073/pnas.0910603106 10.1021/bi00041a033 10.1007/s13346-013-0158-7
ContentType	Journal Article
Copyright	Copyright © 2017 American Chemical Society
Copyright_xml	– notice: Copyright © 2017 American Chemical Society
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1021/acsnano.7b04734
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Engineering
EISSN	1936-086X
EndPage	7586
ExternalDocumentID	28727419 10_1021_acsnano_7b04734 a90312194
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	- 23M 53G 55A 5GY 7~N AABXI ABMVS ABUCX ACGFS ACS AEESW AENEX AFEFF ALMA_UNASSIGNED_HOLDINGS AQSVZ CS3 EBS ED ED~ EJD F5P GNL IH9 IHE JG JG~ P2P RNS ROL UI2 VF5 VG9 W1F XKZ YZZ --- .K2 4.4 5VS 6J9 AAHBH AAYXX ABBLG ABJNI ABLBI ABQRX ACBEA ACGFO ADHGD ADHLV AHGAQ BAANH CITATION CUPRZ GGK CGR CUY CVF ECM EIF NPM 7X8
ID	FETCH-LOGICAL-a440t-85cd9fd52f869a669fcf6c7712c9d3e6f1e6317fbb1b4ca640f2470d90c2c0083
IEDL.DBID	ACS
ISICitedReferencesCount	171
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000408520900004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1936-0851 1936-086X
IngestDate	Wed Oct 01 14:01:00 EDT 2025 Thu Jan 02 23:02:30 EST 2025 Sat Nov 29 07:54:28 EST 2025 Tue Nov 18 21:31:37 EST 2025 Thu Aug 27 13:42:12 EDT 2020
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	8
Keywords	toxicity RNAi therapeutics lipidoids delivery lipid nanoparticles RNA interference cationic lipids ionizable amino lipids gene silencing siRNA
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-a440t-85cd9fd52f869a669fcf6c7712c9d3e6f1e6317fbb1b4ca640f2470d90c2c0083
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0003-4408-8350
OpenAccessLink	https://zenodo.org/record/3506671
PMID	28727419
PQID	1922503971
PQPubID	23479
PageCount	15
ParticipantIDs	proquest_miscellaneous_1922503971 pubmed_primary_28727419 crossref_citationtrail_10_1021_acsnano_7b04734 crossref_primary_10_1021_acsnano_7b04734 acs_journals_10_1021_acsnano_7b04734
ProviderPackageCode	JG~ 55A AABXI GNL VF5 XKZ 7~N VG9 W1F ACS AEESW AFEFF ABMVS ABUCX IH9 AQSVZ ED~ UI2
PublicationCentury	2000
PublicationDate	2017-08-22
PublicationDateYYYYMMDD	2017-08-22
PublicationDate_xml	– month: 08 year: 2017 text: 2017-08-22 day: 22
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	ACS nano
PublicationTitleAlternate	ACS Nano
PublicationYear	2017
Publisher	American Chemical Society
Publisher_xml	– name: American Chemical Society
References	ref45/cit45 Renneisen K. (ref91/cit91) 1990; 265 ref3/cit3 ref81/cit81 ref16/cit16 ref52/cit52 ref23/cit23 ref110/cit110 ref2/cit2 ref77/cit77 ref71/cit71 Chonn A. (ref107/cit107) 1991; 146 Felgner J. H. (ref24/cit24) 1994; 269 ref20/cit20 ref48/cit48 ref74/cit74 ref10/cit10 ref35/cit35 ref89/cit89 ref19/cit19 ref93/cit93 ref96/cit96 ref109/cit109 ref13/cit13 ref105/cit105 ref61/cit61 ref67/cit67 ref38/cit38 ref90/cit90 ref64/cit64 ref54/cit54 ref6/cit6 ref18/cit18 ref65/cit65 ref97/cit97 ref101/cit101 ref11/cit11 ref102/cit102 ref29/cit29 ref76/cit76 ref86/cit86 ref39/cit39 ref43/cit43 ref80/cit80 ref28/cit28 ref55/cit55 ref12/cit12 ref66/cit66 ref22/cit22 ref33/cit33 ref87/cit87 ref106/cit106 Agrawal S. (ref5/cit5) 1997; 209 Bennett C. F. (ref32/cit32) 1992; 41 ref44/cit44 ref70/cit70 ref98/cit98 ref9/cit9 ref27/cit27 ref63/cit63 ref56/cit56 ref92/cit92 ref8/cit8 ref31/cit31 ref59/cit59 ref85/cit85 McLean J. W. (ref42/cit42) 1997; 273 ref34/cit34 ref37/cit37 ref60/cit60 ref88/cit88 ref17/cit17 ref82/cit82 ref53/cit53 ref21/cit21 ref46/cit46 ref49/cit49 ref75/cit75 ref50/cit50 ref78/cit78 ref36/cit36 ref83/cit83 ref79/cit79 ref100/cit100 ref25/cit25 ref103/cit103 ref72/cit72 ref14/cit14 ref57/cit57 ref51/cit51 ref40/cit40 ref68/cit68 ref94/cit94 Gottschalk S. (ref99/cit99) 1994; 1 ref26/cit26 ref73/cit73 ref69/cit69 ref15/cit15 ref62/cit62 ref41/cit41 ref58/cit58 ref95/cit95 ref108/cit108 ref104/cit104 ref4/cit4 ref30/cit30 ref47/cit47 ref84/cit84 ref1/cit1 ref7/cit7
References_xml	– ident: ref18/cit18 doi: 10.1021/bi00152a045 – ident: ref103/cit103 doi: 10.1038/mtna.2012.28 – ident: ref106/cit106 doi: 10.1016/0005-2736(94)90231-3 – volume: 269 start-page: 2550 year: 1994 ident: ref24/cit24 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)41980-6 – volume: 1 start-page: 185 year: 1994 ident: ref99/cit99 publication-title: Gene Ther. – ident: ref85/cit85 doi: 10.1038/nnano.2007.387 – volume: 146 start-page: 4234 year: 1991 ident: ref107/cit107 publication-title: J. Immunol. doi: 10.4049/jimmunol.146.12.4234 – ident: ref31/cit31 doi: 10.1126/science.7684856 – ident: ref70/cit70 doi: 10.1371/journal.pone.0133154 – ident: ref101/cit101 doi: 10.1038/nnano.2012.168 – ident: ref109/cit109 doi: 10.1016/S0014-5793(96)01397-X – ident: ref52/cit52 doi: 10.1038/mtna.2016.40 – ident: ref3/cit3 doi: 10.1016/0169-409X(95)00020-8 – ident: ref13/cit13 doi: 10.1073/pnas.84.21.7413 – ident: ref64/cit64 doi: 10.1021/bc300346h – ident: ref81/cit81 doi: 10.1016/j.jacc.2013.11.023 – ident: ref84/cit84 doi: 10.1016/j.ajps.2014.08.011 – ident: ref90/cit90 doi: 10.1021/acs.nanolett.5b01362 – ident: ref54/cit54 doi: 10.1016/j.ijpharm.2017.01.016 – ident: ref95/cit95 doi: 10.1021/nn506248s – ident: ref86/cit86 doi: 10.1073/pnas.0707461104 – ident: ref80/cit80 doi: 10.1126/scitranslmed.aaf1435 – ident: ref41/cit41 doi: 10.1016/j.addr.2004.12.004 – ident: ref47/cit47 doi: 10.1038/nmat3765 – ident: ref6/cit6 doi: 10.1186/1758-907X-1-14 – ident: ref48/cit48 doi: 10.1016/j.jconrel.2005.06.014 – ident: ref56/cit56 doi: 10.1074/jbc.270.32.18997 – ident: ref74/cit74 doi: 10.1038/nbt.2614 – ident: ref93/cit93 doi: 10.1021/acsnano.5b02796 – ident: ref83/cit83 doi: 10.1038/mtna.2016.68 – ident: ref26/cit26 doi: 10.1016/S0168-3659(99)00158-3 – ident: ref76/cit76 doi: 10.1038/mt.2016.179 – ident: ref53/cit53 doi: 10.1073/pnas.1619653114 – ident: ref51/cit51 doi: 10.1038/mt.2013.124 – ident: ref59/cit59 doi: 10.1038/sj.gt.3301506 – ident: ref62/cit62 doi: 10.1016/S0005-2736(01)00399-6 – volume: 265 start-page: 16337 year: 1990 ident: ref91/cit91 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)46228-4 – ident: ref79/cit79 doi: 10.1161/CIRCULATIONAHA.112.000116 – ident: ref50/cit50 doi: 10.1073/pnas.1306529110 – ident: ref55/cit55 doi: 10.1073/pnas.93.21.11493 – ident: ref7/cit7 doi: 10.1016/j.jconrel.2006.04.014 – ident: ref45/cit45 doi: 10.1002/anie.201203263 – ident: ref88/cit88 doi: 10.1016/j.jconrel.2013.09.013 – ident: ref75/cit75 doi: 10.1038/nbt.2612 – ident: ref33/cit33 doi: 10.1089/hum.1992.3.3-267 – ident: ref67/cit67 doi: 10.1038/nature04688 – ident: ref20/cit20 doi: 10.1016/j.abb.2004.12.010 – ident: ref21/cit21 doi: 10.1073/pnas.94.4.1160 – ident: ref38/cit38 doi: 10.1016/j.biomaterials.2010.05.027 – ident: ref49/cit49 doi: 10.1038/nbt.1602 – ident: ref58/cit58 doi: 10.1016/S0005-2736(00)00226-1 – ident: ref57/cit57 doi: 10.1016/S0005-2736(96)00241-6 – ident: ref94/cit94 doi: 10.1073/pnas.1519273113 – ident: ref44/cit44 doi: 10.1016/S0005-2736(00)00343-6 – ident: ref16/cit16 doi: 10.1111/j.1749-6632.1994.tb21701.x – ident: ref30/cit30 doi: 10.1007/s11745-005-1446-5 – ident: ref82/cit82 doi: 10.1038/mtna.2011.3 – ident: ref39/cit39 doi: 10.3109/08982109709035481 – ident: ref96/cit96 doi: 10.1126/science.1149859 – ident: ref108/cit108 doi: 10.1038/nbt1081 – ident: ref9/cit9 doi: 10.1039/f29767201525 – ident: ref11/cit11 doi: 10.1021/la201464k – ident: ref46/cit46 doi: 10.1021/bi971772j – ident: ref87/cit87 doi: 10.1021/mp800049w – ident: ref23/cit23 doi: 10.1016/S0005-2736(98)00002-9 – ident: ref29/cit29 doi: 10.1016/j.bmcl.2005.04.010 – ident: ref17/cit17 doi: 10.1016/0005-2736(92)90316-E – ident: ref78/cit78 doi: 10.1038/nbt.1989 – volume: 41 start-page: 1023 year: 1992 ident: ref32/cit32 publication-title: Mol. Pharmacol. doi: 10.1016/S0026-895X(25)09229-6 – ident: ref27/cit27 doi: 10.1021/mp400467x – ident: ref40/cit40 doi: 10.1023/A:1018932714745 – ident: ref2/cit2 doi: 10.1038/nrd2310 – ident: ref63/cit63 doi: 10.1016/j.jconrel.2012.12.014 – ident: ref77/cit77 doi: 10.1038/nbt.2634 – ident: ref15/cit15 doi: 10.1021/jm000006z – ident: ref98/cit98 doi: 10.1016/j.ejpb.2008.06.026 – ident: ref89/cit89 doi: 10.1158/0008-5472.CAN-05-4199 – ident: ref25/cit25 doi: 10.1021/jm010918g – ident: ref66/cit66 doi: 10.1038/nbt1122 – ident: ref36/cit36 doi: 10.1016/j.addr.2012.06.013 – ident: ref14/cit14 doi: 10.1038/sj.gt.3301471 – ident: ref97/cit97 doi: 10.1038/mt.2010.85 – ident: ref72/cit72 doi: 10.1038/ncomms5277 – ident: ref100/cit100 doi: 10.1517/17425247.2012.642363 – ident: ref65/cit65 doi: 10.1021/jp303267y – ident: ref8/cit8 doi: 10.1016/j.biomaterials.2008.04.036 – ident: ref104/cit104 doi: 10.1021/ja301621z – ident: ref105/cit105 doi: 10.1021/acs.jpcb.5b02891 – ident: ref37/cit37 doi: 10.1002/(SICI)1521-2254(199903/04)1:2<111::AID-JGM22>3.3.CO;2-P – ident: ref73/cit73 doi: 10.1177/1535370216640944 – ident: ref28/cit28 doi: 10.1016/j.nano.2012.05.019 – ident: ref61/cit61 doi: 10.1016/j.ymthe.2004.12.018 – ident: ref68/cit68 doi: 10.1038/nbt1402 – ident: ref71/cit71 doi: 10.1007/s12195-016-0436-9 – ident: ref92/cit92 doi: 10.1038/mt.2009.271 – ident: ref4/cit4 doi: 10.1016/0024-3205(91)90480-Y – ident: ref1/cit1 doi: 10.1038/nature03121 – ident: ref102/cit102 doi: 10.1038/mt.2009.208 – ident: ref43/cit43 doi: 10.3109/10611869509059214 – ident: ref60/cit60 doi: 10.1038/mt.2011.56 – ident: ref12/cit12 doi: 10.1016/j.jconrel.2006.06.024 – ident: ref10/cit10 doi: 10.1039/b609510k – ident: ref34/cit34 doi: 10.1016/0006-291X(92)90565-3 – ident: ref110/cit110 doi: 10.1038/nrd4685 – ident: ref22/cit22 doi: 10.1002/chem.200305232 – volume: 273 start-page: H387 year: 1997 ident: ref42/cit42 publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.1997.273.1.H387 – ident: ref69/cit69 doi: 10.1073/pnas.0910603106 – ident: ref19/cit19 doi: 10.1021/bi00041a033 – volume: 209 start-page: 60 year: 1997 ident: ref5/cit5 publication-title: Ciba Found. Symp. – ident: ref35/cit35 doi: 10.1007/s13346-013-0158-7
SSID	ssj0057876
Score	2.6027226
SecondaryResourceType	review_article
Snippet	RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains...
SourceID	proquest pubmed crossref acs
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	7572
SubjectTerms	Animals Cations - chemistry Gene Silencing - physiology Humans Lipids - chemistry Nanoparticles - chemistry RNA Interference - physiology RNA, Small Interfering - genetics RNA, Small Interfering - physiology
Title	Next-Generation Lipids in RNA Interference Therapeutics
URI	http://dx.doi.org/10.1021/acsnano.7b04734 https://www.ncbi.nlm.nih.gov/pubmed/28727419 https://www.proquest.com/docview/1922503971
Volume	11
WOSCitedRecordID	wos000408520900004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVABC databaseName: American Chemical Society Journals customDbUrl: eissn: 1936-086X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0057876 issn: 1936-0851 databaseCode: ACS dateStart: 20070801 isFulltext: true titleUrlDefault: https://pubs.acs.org/action/showPublications?display=journals providerName: American Chemical Society
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV07T8MwED7RwgAD70d5VEHqwJJiu64dj1VFxYAiBAV1i2zHliqhFDUtvx87SVseqgRLptjyPXL3Xc7-DNDCXDFCtQglwzakyrBQYeF82T0ZZoaQgr749YHHcTQaiccVWfTPDj7Bt1Lnmcwmba4Q5R1ag03iQK7fvdfrPy-Crvc7VjaQXYHsUMSSxefXBD4N6fx7GlqDLYscM9j7x-r2YbcCkkGvtPwBbJjsEHa-0AseAY99WVsSS3v9B_6i6jQPxlnwFPeC4mdgddwvGK7OYeXH8DK4G_bvw-qihFBSimZh1NWpsGmX2IgJyZiw2jLNOSZapB3DLDbM4QSrFFZUS0aRJZSjVCBNtAdhJ1DPJpk5g4AoB6gimyLPxGW0UqmTUncwk1xpomQDWk7kpHL0PCl62AQnlR6SSg8NaC_Um-iKbNzfefG2fsDNcsB7ybOx_tXrhb0S9y34BofMzGTuFiNcdEIOYeEGnJaGXE7mKkPP1CPO_ybABWwTn8CRiyPkEuqz6dxcwZb-mI3zaRNqfBQ1Cw_8BMy_1Lo
linkProvider	American Chemical Society
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dS8MwED_8AvXB74_5WWEPvnQmWZYsj0MUxVlEp_hWmjSBgXSyTv9-L223KTLQlz6U5rgk17tfctzvAOpUasG4UWEiqAu5tiLUVKEt41NQYRkr6ItfujKK2q-v6mEOyLgWBpXIUVJeJPGn7AL0At9lSTZoSE24bPJ5WGxhcPU9CzqXT2Pf681PlHlkPCcjmJiQ-fwS4KORyX9GoxkQswg11-v_V3ID1ipYGXRKO9iEOZttweo3ssFtkJE_5JY00343At-2Os2DfhY8Rp2guBqsiv-C3rQqK9-B5-ur3uVNWLVNCBPOyShst0yqXNpiri1UIoRyxgkjJWVGpU0rHLUCUYPTmmpuEsGJY1ySVBHDjIdku7CQDTK7DwHTCK_aLiWel8sarVOcpWlSkUhtmE5qUMcpx5XZ53GR0WY0rtYhrtahBo3xKsemoh73HTDeZg84nwx4L1k3Zn96Nt62GP8Mn-5IMjv4QGUU-iqCeIvWYK_cz4kwPCd63h518LcJnMLyTe--G3dvo7tDWGE-tBP0MOwIFkbDD3sMS-Zz1M-HJ4U5fgERVtw4
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwED90iuiD3x_zs4IPvnQ2WZYsj2M6FKWITvGtNGkCA-nEbv79XtpsKjIQX_pQmnC5XO5-6XG_AzgjQnHKtAxTTmzIlOGhIhJtGZ-ccENpSV_8fCfiuP3yIu99UZirhUEhCpypKJP47lS_ZdYzDJALfJ-n-bAhVMREk83DQgvDuetb0Ok-TvyvM0Fe5ZLxroyAYkro82sCF5F08TMizYCZZbjprf1P0HVY9fAy6FT2sAFzJt-ElW-kg1sgYnfZreim3a4Ern11VgSDPHiIO0H5i9AXAQb9r-qsYhueelf97nXo2yeEKWPRKGy3dCZt1qK2zWXKubTaci0EoVpmTcMtMRzRg1WKKKZTziJLmYgyGWmqHTTbgVo-zM0eBFQhzGrbLHL8XEYrleEqdZPwVChNVVqHM1xy4s2_SMrMNiWJ10Pi9VCHxkTTifYU5K4TxuvsAefTAW8V-8bsT08nW5fgCXFpjzQ3wzEKI9FnRYi7SB12qz2dTob3RcffI_f_toATWLq_7CV3N_HtASxTF-EjdDT0EGqj97E5gkX9MRoU78elRX4CRLDesg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Next-Generation+Lipids+in+RNA+Interference+Therapeutics&rft.jtitle=ACS+nano&rft.au=Rietwyk%2C+Stephanie&rft.au=Peer%2C+Dan&rft.date=2017-08-22&rft.pub=American+Chemical+Society&rft.issn=1936-0851&rft.eissn=1936-086X&rft.volume=11&rft.issue=8&rft.spage=7572&rft.epage=7586&rft_id=info:doi/10.1021%2Facsnano.7b04734&rft.externalDocID=a90312194
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1936-0851&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1936-0851&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1936-0851&client=summon