Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

The systematic discovery of functional fragments binding to the composite interface of protein complexes is a first critical step for the development of orthosteric stabilizers of protein-protein interactions (PPIs). We have previously shown that disulfide trapping successfully yielded covalent stab...

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Bibliographic Details

Published in:	ACS medicinal chemistry letters Vol. 12; no. 6; p. 976
Main Authors:	Sijbesma, Eline, Hallenbeck, Kenneth K, Andrei, Sebastian A, Rust, Reanne R, Adriaans, Joris M C, Brunsveld, Luc, Arkin, Michelle R, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	10.06.2021
ISSN:	1948-5875, 1948-5875
Online Access:	Get more information
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