Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ

A macrocyclization approach has been explored on a series of benzoxazine phosphoinositide 3-kinase delta inhibitors, resulting in compounds with improved potency, permeability, and in vivo clearance while maintaining good solubility. The thermodynamics of binding was explored via surface plasmon res...

Celý popis

Podrobná bibliografia

Vydané v:	ACS medicinal chemistry letters Ročník 11; číslo 7; s. 1386 - 1391
Hlavní autori:	Spencer, Jonathan A., Baldwin, Ian R., Barton, Nick, Chung, Chun-Wa, Convery, Maire A., Edwards, Christopher D., Jamieson, Craig, Mallett, David N., Rowedder, James E., Rowland, Paul, Thomas, Daniel A., Hardy, Charlotte J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	WASHINGTON Amer Chemical Soc 09.07.2020
Predmet:	Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology Thermodynamics POTENT Lipid kinase OPTIMIZATION PI3K delta INHIBITORS BINDING DISCOVERY Macrocycle
ISSN:	1948-5875, 1948-5875
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!