Fast DNA Sequencing via Transverse Electronic Transport

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estima...

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Published in:	Nano letters Vol. 6; no. 4; pp. 779 - 782
Main Authors:	Lagerqvist, Johan, Zwolak, Michael, Di Ventra, Massimiliano
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01.04.2006
Subjects:	Biological and medical sciences Biosensing Techniques - instrumentation Biosensing Techniques - methods Computer Simulation Computer-Aided Design Conformational dynamics in molecular biology DNA - analysis DNA - chemistry DNA - radiation effects Electrochemistry - instrumentation Electrochemistry - methods Electrodes Electron Transport Feasibility Studies Fundamental and applied biological sciences. Psychology Models, Chemical Molecular biophysics Oligonucleotide Array Sequence Analysis - instrumentation Oligonucleotide Array Sequence Analysis - methods Sequence Analysis, DNA - instrumentation Sequence Analysis, DNA - methods Human Nucleotide sequence DNA DNA sequence Nanopore Genome Implementation Nanoporosity
ISSN:	1530-6984, 1530-6992
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Abstract	A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual.
AbstractList	A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual. A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual.A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual. A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, e.g., orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict and cure diseases from the perspective of the genetic makeup of each individual.
Author	Lagerqvist, Johan Di Ventra, Massimiliano Zwolak, Michael
AuthorAffiliation	2 Physics Department, California Institute of Technology, Pasadena, CA 91125 1 Department of Physics, University of California, San Diego, La Jolla, CA 92093-0319
AuthorAffiliation_xml	– name: 1 Department of Physics, University of California, San Diego, La Jolla, CA 92093-0319 – name: 2 Physics Department, California Institute of Technology, Pasadena, CA 91125
Author_xml	– sequence: 1 givenname: Johan surname: Lagerqvist fullname: Lagerqvist, Johan – sequence: 2 givenname: Michael surname: Zwolak fullname: Zwolak, Michael – sequence: 3 givenname: Massimiliano surname: Di Ventra fullname: Di Ventra, Massimiliano
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Snippet	A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for...
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SubjectTerms	Biological and medical sciences Biosensing Techniques - instrumentation Biosensing Techniques - methods Computer Simulation Computer-Aided Design Conformational dynamics in molecular biology DNA - analysis DNA - chemistry DNA - radiation effects Electrochemistry - instrumentation Electrochemistry - methods Electrodes Electron Transport Feasibility Studies Fundamental and applied biological sciences. Psychology Models, Chemical Molecular biophysics Oligonucleotide Array Sequence Analysis - instrumentation Oligonucleotide Array Sequence Analysis - methods Sequence Analysis, DNA - instrumentation Sequence Analysis, DNA - methods
Title	Fast DNA Sequencing via Transverse Electronic Transport
URI	http://dx.doi.org/10.1021/nl0601076 https://www.ncbi.nlm.nih.gov/pubmed/16608283 https://www.proquest.com/docview/67856581 https://pubmed.ncbi.nlm.nih.gov/PMC2556950
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