Comprehensive identification of glycated peptides and their glycation motifs in plasma and erythrocytes of control and diabetic subjects

Nonenzymatic glycation of proteins sets the stage for formation of advanced glycation end-products and development of chronic complications of diabetes. In this report, we extended our previous methods on proteomics analysis of glycated proteins to comprehensively identify glycated proteins in contr...

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Veröffentlicht in:	Journal of proteome research Jg. 10; H. 7; S. 3076
Hauptverfasser:	Zhang, Qibin, Monroe, Matthew E, Schepmoes, Athena A, Clauss, Therese R W, Gritsenko, Marina A, Meng, Da, Petyuk, Vladislav A, Smith, Richard D, Metz, Thomas O
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2011
Schlagworte:	Amino Acid Motifs Biomarkers - blood Biomarkers - chemistry Blood Proteins - analysis Blood Proteins - chemistry Chromatography, Affinity Chromatography, High Pressure Liquid Diabetes Complications - blood Diabetes Complications - physiopathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Erythrocytes - chemistry Glycation End Products, Advanced - blood Glycation End Products, Advanced - chemistry Glycopeptides - blood Glycopeptides - chemistry Glycosylation Humans Hyperglycemia - blood Hyperglycemia - physiopathology Molecular Sequence Data Peptide Fragments - blood Peptide Fragments - chemistry Plasma - chemistry Proteomics - methods Tandem Mass Spectrometry Trypsin - metabolism
ISSN:	1535-3907, 1535-3907
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