Establishment and Validation of Competitive Counterflow as a Method To Detect Substrates of the Organic Anion Transporting Polypeptide 2B1

The organic anion transporting polypeptide (OATP) 2B1 is ubiquitously expressed and known to facilitate cellular entry. It is widely accepted that transport proteins play a pivotal role in pharmacokinetics. Consequently, testing for interaction with drug transporters became an important part in the...

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Vydáno v:	Molecular pharmaceutics Ročník 15; číslo 12; s. 5501
Hlavní autoři:	Schäfer, Anima M, Bock, Thomas, Meyer Zu Schwabedissen, Henriette E
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 03.12.2018
Témata:	Animals Chemistry, Pharmaceutical - instrumentation Chemistry, Pharmaceutical - methods Dogs Drug Interactions Estrone - analogs & derivatives Estrone - pharmacokinetics HeLa Cells Hep G2 Cells Humans Madin Darby Canine Kidney Cells Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Small Molecule Libraries - pharmacokinetics Substrate Specificity organic anion transport competitive counterflow drug transporter substrate identification OATP2B1
ISSN:	1543-8392, 1543-8392
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