Bone Scaffolds: An Incorporation of Biomaterials, Cells, and Biofactors

Large injuries to bones are still one of the most challenging musculoskeletal problems. Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in resolving this complication. Therefore, this review aims to provide information on the recent advances made to utilize th...

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Bibliographic Details
Published in:ACS biomaterials science & engineering Vol. 7; no. 12; p. 5397
Main Authors: Bahraminasab, Marjan, Janmohammadi, Mahsa, Arab, Samaneh, Talebi, Athar, Nooshabadi, Vajihe Taghdiri, Koohsarian, Parisa, Nourbakhsh, Mohammad Sadegh
Format: Journal Article
Language:English
Published: United States 13.12.2021
Subjects:
Biocompatible Materials
Bone and Bones
Bone Regeneration
Stem Cells
Tissue Engineering
bioactive glasses
biodegradable metals
stem cells
growth factors
calcium phosphate
biodegradable polymers
exosome
ISSN:2373-9878, 2373-9878
Online Access:Get more information
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Summary:Large injuries to bones are still one of the most challenging musculoskeletal problems. Tissue engineering can combine stem cells, scaffold biomaterials, and biofactors to aid in resolving this complication. Therefore, this review aims to provide information on the recent advances made to utilize the potential of biomaterials for making bone scaffolds and the assisted stem cell therapy and use of biofactors for bone tissue engineering. The requirements and different types of biomaterials used for making scaffolds are reviewed. Furthermore, the importance of stem cells and biofactors (growth factors and extracellular vesicles) in bone regeneration and their use in bone scaffolds and the key findings are discussed. Lastly, some of the main obstacles in bone tissue engineering and future trends are highlighted.
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ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.1c00920