c-Myc-Targeting PROTAC Based on a TNA-DNA Bivalent Binder for Combination Therapy of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is highly aggressive with a poor clinical prognosis and no targeted therapy. The c-Myc protein is a master transcription factor and a potential therapeutic target for TNBC. In this study, we develop a PROTAC (PROteolysis TArgeting Chimera) based on TNA (threose n...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society Jg. 145; H. 16; S. 9334
Hauptverfasser:	Li, Xintong, Zhang, Ze, Gao, Fangyan, Ma, Yuxuan, Wei, Dongying, Lu, Zhangwei, Chen, Siqi, Wang, Mengqi, Wang, Yueyao, Xu, Kun, Wang, Runtian, Xu, Feng, Chen, Jia-Yu, Zhu, Chengjun, Li, Zhe, Yu, Hanyang, Guan, Xiaoxiang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 26.04.2023
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Line, Tumor Cell Proliferation Disease Models, Animal Genes, myc Humans Mice Transcription Factors Triple Negative Breast Neoplasms - pathology
ISSN:	1520-5126, 1520-5126
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!