Unravelling the Non-Native Low-Spin State of the Cytochrome c-Cardiolipin Complex: Evidence of the Formation of a His-Ligated Species Only

The interaction between cytochrome c (Cyt c) and cardiolipin (CL) plays a vital role in the early stages of apoptosis. The binding of CL to Cyt c induces a considerable increase in its peroxidase activity that has been attributed to the partial unfolding of the protein, dissociation of the Met80 axi...

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Bibliographic Details
Published in:	Biochemistry (Easton) Vol. 56; no. 13; p. 1887
Main Authors:	Milazzo, Lisa, Tognaccini, Lorenzo, Howes, Barry D, Sinibaldi, Federica, Piro, Maria C, Fittipaldi, Maria, Baratto, Maria C, Pogni, Rebecca, Santucci, Roberto, Smulevich, Giulietta
Format:	Journal Article
Language:	English
Published:	United States 04.04.2017
Subjects:	Animals Carbon Monoxide - chemistry Cardiolipins - chemistry Cardiolipins - metabolism Cloning, Molecular Cytochromes c - chemistry Cytochromes c - genetics Cytochromes c - metabolism Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Genes, Synthetic Histidine - chemistry Horses Hydrogen Bonding Methionine - chemistry Myocardium - chemistry Protein Binding Protein Folding Protein Structure, Secondary Protein Unfolding Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Temperature
ISSN:	1520-4995, 1520-4995
Online Access:	Get more information
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