Genetically Encoded Molecular Tension Probe for Tracing Protein-Protein Interactions in Mammalian Cells

Optical imaging of protein-protein interactions (PPIs) facilitates comprehensive elucidation of intracellular molecular events. We demonstrate an optical measure for visualizing molecular tension triggered by any PPI in mammalian cells. Twenty-three kinds of candidate designs were fabricated, in whi...

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Bibliographic Details
Published in:	Bioconjugate chemistry Vol. 27; no. 2; p. 354
Main Authors:	Kim, Sung Bae, Nishihara, Ryo, Citterio, Daniel, Suzuki, Koji
Format:	Journal Article
Language:	English
Published:	United States 17.02.2016
Subjects:	Amino Acid Sequence Animals Biomechanical Phenomena Cercopithecus aethiops COS Cells Humans Luciferases, Renilla - chemistry Luciferases, Renilla - metabolism Luminescent Measurements - methods Molecular Probes - chemistry Molecular Probes - metabolism Molecular Sequence Data Protein Binding Protein Interaction Mapping - methods Protein Structure, Tertiary Renilla - chemistry Renilla - enzymology Tacrolimus Binding Proteins - chemistry Tacrolimus Binding Proteins - metabolism TOR Serine-Threonine Kinases - chemistry TOR Serine-Threonine Kinases - metabolism
ISSN:	1520-4812, 1520-4812
Online Access:	Get more information
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