Nanopore-based targeted sequencing test for direct tuberculosis identification, genotyping, and detection of drug resistance mutations: a side-by-side comparison of targeted next-generation sequencing technologies

We investigated the performance of the targeted next-generation sequencing (tNGS)-based Oxford Nanopore Diagnostics AmPORE TB assay, recently approved by the World Health Organization (WHO) as tuberculosis (TB) diagnostic test for the detection of drug resistance on respiratory specimens. A total of...

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Bibliographic Details
Published in:	Journal of clinical microbiology Vol. 62; no. 10; p. e0081524
Main Authors:	Cabibbe, Andrea Maurizio, Moghaddasi, Kiarash, Batignani, Virginia, Morgan, Godstime Stephen Kojo, Di Marco, Federico, Cirillo, Daniela Maria
Format:	Journal Article
Language:	English
Published:	United States 16.10.2024
Subjects:	Antitubercular Agents - pharmacology DNA, Bacterial - genetics Drug Resistance, Bacterial - genetics Genotype Genotyping Techniques - methods High-Throughput Nucleotide Sequencing - methods Humans Molecular Diagnostic Techniques - methods Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Nanopore Sequencing - methods Nanopores Sputum - microbiology Tuberculosis - diagnosis Tuberculosis - microbiology Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - microbiology rapid tuberculosis laboratory diagnosis respiratory samples targeted next-generation sequencing drug-resistant tuberculosis
ISSN:	1098-660X, 1098-660X
Online Access:	Get more information
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