Phage-antibiotic synergy against daptomycin-nonsusceptible MRSA in an ex vivo simulated endocardial pharmacokinetic/pharmacodynamic model

Phage-antibiotic combinations (PAC) offer a potential solution for treating refractory daptomycin-nonsusceptible (DNS) methicillin-resistant (MRSA) infections. We examined PAC activity against two well-characterized DNS MRSA strains (C4 and C37) and . PACs comprising daptomycin (DAP) ± ceftaroline (...

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Bibliographic Details

Published in:	Antimicrobial agents and chemotherapy Vol. 68; no. 4; p. e0138823
Main Authors:	Kunz Coyne, Ashlan J, Bleick, Callan, Stamper, Kyle, Kebriaei, Razieh, Bayer, Arnold S, Lehman, Susan M, Rybak, Michael J
Format:	Journal Article
Language:	English
Published:	United States 03.04.2024
Subjects:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Ceftaroline Cephalosporins - pharmacology Daptomycin - pharmacology Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests daptomycin-nonsusceptible synergy antibiotics bacteriophage MRSA
ISSN:	1098-6596, 1098-6596
Online Access:	Get more information
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