Overexpression of T3SS translocation signals in Salmonella causes delayed attenuation

Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target effects. We previously engineered serovar Typhimurium to overexpress the secretion signal of the type 3 secretion system effector SspH1 fused...

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Veröffentlicht in:	Infection and immunity Jg. 92; H. 1; S. e0032923
Hauptverfasser:	Abele, Taylor J, Billman, Zachary P, Harvest, Carissa K, Bryan, Alexia K, Larson, Heather N, Coers, Jörn, Miao, Edward A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.01.2024
Schlagworte:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Mice Salmonella typhimurium Type III Secretion Systems - genetics Virulence Virulence Factors - metabolism Salmonella T3SS attenuation
ISSN:	1098-5522, 1098-5522
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