Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014
A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0...
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| Vydané v: | Antimicrobial agents and chemotherapy Ročník 60; číslo 12; s. 7490 - 7493 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
01.12.2016
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| ISSN: | 1098-6596 |
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| Abstract | A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0.4% to 3.9% during the 10-year surveillance period. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence type (MLST) analysis revealed that 37 optrA-positive Enterococcus faecalis isolates clustered into 25 PFGE patterns and 21 sequence types, while 6 Enterococcus faecium isolates represented 6 PFGE patterns and 6 sequence types. The present study underscores the importance of routine and persistent monitoring of oxazolidinone resistance and optrA gene. |
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| AbstractList | A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0.4% to 3.9% during the 10-year surveillance period. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence type (MLST) analysis revealed that 37 optrA-positive Enterococcus faecalis isolates clustered into 25 PFGE patterns and 21 sequence types, while 6 Enterococcus faecium isolates represented 6 PFGE patterns and 6 sequence types. The present study underscores the importance of routine and persistent monitoring of oxazolidinone resistance and optrA gene. |
| Author | Wang, Yang Cui, Lanqing Song, Yunjia Li, Yun Yang, Weiwei Liu, Jian Xue, Feng Lv, Yuan Wang, Shan Zhang, Jia |
| Author_xml | – sequence: 1 givenname: Lanqing surname: Cui fullname: Cui, Lanqing organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China – sequence: 2 givenname: Yang surname: Wang fullname: Wang, Yang organization: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China – sequence: 3 givenname: Yuan surname: Lv fullname: Lv, Yuan email: lvyuan0901@sina.com organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China lvyuan0901@sina.com – sequence: 4 givenname: Shan surname: Wang fullname: Wang, Shan organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China – sequence: 5 givenname: Yunjia surname: Song fullname: Song, Yunjia organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China – sequence: 6 givenname: Yun surname: Li fullname: Li, Yun organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China – sequence: 7 givenname: Jian surname: Liu fullname: Liu, Jian organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China – sequence: 8 givenname: Feng surname: Xue fullname: Xue, Feng organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China – sequence: 9 givenname: Weiwei surname: Yang fullname: Yang, Weiwei organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China – sequence: 10 givenname: Jia surname: Zhang fullname: Zhang, Jia organization: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China |
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| SubjectTerms | Anti-Bacterial Agents - pharmacology China - epidemiology Drug Resistance, Bacterial - genetics Electrophoresis, Gel, Pulsed-Field Enterococcus faecalis - drug effects Enterococcus faecalis - genetics Enterococcus faecalis - growth & development Enterococcus faecalis - isolation & purification Enterococcus faecium - drug effects Enterococcus faecium - genetics Enterococcus faecium - growth & development Enterococcus faecium - isolation & purification Genes, Bacterial Genotype Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - epidemiology Gram-Positive Bacterial Infections - microbiology Humans Microbial Sensitivity Tests Multilocus Sequence Typing Mutation Oxazolidinones - pharmacology Public Health Surveillance |
| Title | Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014 |
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