Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014

A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy Vol. 60; no. 12; pp. 7490 - 7493
Main Authors: Cui, Lanqing, Wang, Yang, Lv, Yuan, Wang, Shan, Song, Yunjia, Li, Yun, Liu, Jian, Xue, Feng, Yang, Weiwei, Zhang, Jia
Format: Journal Article
Language:English
Published: United States 01.12.2016
Subjects:
Anti-Bacterial Agents - pharmacology
China - epidemiology
Drug Resistance, Bacterial - genetics
Electrophoresis, Gel, Pulsed-Field
Enterococcus faecalis - drug effects
Enterococcus faecalis - genetics
Enterococcus faecalis - growth & development
Enterococcus faecalis - isolation & purification
Enterococcus faecium - drug effects
Enterococcus faecium - genetics
Enterococcus faecium - growth & development
Enterococcus faecium - isolation & purification
Genes, Bacterial
Genotype
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - epidemiology
Gram-Positive Bacterial Infections - microbiology
Humans
Microbial Sensitivity Tests
Multilocus Sequence Typing
Mutation
Oxazolidinones - pharmacology
Public Health Surveillance
ISSN:1098-6596
Online Access:Get more information
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Summary:A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0.4% to 3.9% during the 10-year surveillance period. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence type (MLST) analysis revealed that 37 optrA-positive Enterococcus faecalis isolates clustered into 25 PFGE patterns and 21 sequence types, while 6 Enterococcus faecium isolates represented 6 PFGE patterns and 6 sequence types. The present study underscores the importance of routine and persistent monitoring of oxazolidinone resistance and optrA gene.
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ISSN:1098-6596
DOI:10.1128/AAC.01256-16