Finding Order in the Chaos: Outstanding Questions in Klebsiella pneumoniae Pathogenesis

are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range of infections that are often difficult to treat. These infections are caused by different pathotypes of , called either classical or hypervirulent strains. These...

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Veröffentlicht in:	Infection and immunity Jg. 89; H. 4
Hauptverfasser:	Gonzalez-Ferrer, Shekina, Peñaloza, Hernán F, Budnick, James A, Bain, William G, Nordstrom, Hayley R, Lee, Janet S, Van Tyne, Daria
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.03.2021
Schlagworte:	Animals Disease Susceptibility Geography, Medical Global Health Host-Pathogen Interactions - immunology Humans Immunity, Innate Klebsiella Infections - epidemiology Klebsiella Infections - immunology Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - pathogenicity Klebsiella pneumoniae - physiology Population Surveillance Virulence Klebsiella pathogenesis evolution innate immune system
ISSN:	1098-5522, 1098-5522
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Abstract	are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range of infections that are often difficult to treat. These infections are caused by different pathotypes of , called either classical or hypervirulent strains. These two groups are genetically distinct, inhabit nonoverlapping geographies, and cause different types of harmful infections in humans. These distinct bacterial groups have also been found to interact differently with the host immune system. Initial innate immune defenses against infection include complement, macrophages, neutrophils, and monocytes; these defenses are primary strategies employed by the host to clear infections. pathogenesis depends upon the interactions between the microbe and each of these host defenses, and it is becoming increasingly apparent that bacterial genetic diversity impacts the outcomes of these interactions. Here, we highlight recent advances in our understanding of pathogenesis, with a focus on how bacterial evolution and diversity impact interactions with mammalian innate immune host defenses. We also discuss outstanding questions regarding how can frustrate normal immune responses, capitalize upon states of immunocompromise, and cause infections with high mortality.
AbstractList	Klebsiella pneumoniae are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range of infections that are often difficult to treat. These infections are caused by different pathotypes of K. pneumoniae, called either classical or hypervirulent strains. These two groups are genetically distinct, inhabit nonoverlapping geographies, and cause different types of harmful infections in humans. These distinct bacterial groups have also been found to interact differently with the host immune system. Initial innate immune defenses against K. pneumoniae infection include complement, macrophages, neutrophils, and monocytes; these defenses are primary strategies employed by the host to clear infections. K. pneumoniae pathogenesis depends upon the interactions between the microbe and each of these host defenses, and it is becoming increasingly apparent that bacterial genetic diversity impacts the outcomes of these interactions. Here, we highlight recent advances in our understanding of K. pneumoniae pathogenesis, with a focus on how bacterial evolution and diversity impact K. pneumoniae interactions with mammalian innate immune host defenses. We also discuss outstanding questions regarding how K. pneumoniae can frustrate normal immune responses, capitalize upon states of immunocompromise, and cause infections with high mortality.Klebsiella pneumoniae are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range of infections that are often difficult to treat. These infections are caused by different pathotypes of K. pneumoniae, called either classical or hypervirulent strains. These two groups are genetically distinct, inhabit nonoverlapping geographies, and cause different types of harmful infections in humans. These distinct bacterial groups have also been found to interact differently with the host immune system. Initial innate immune defenses against K. pneumoniae infection include complement, macrophages, neutrophils, and monocytes; these defenses are primary strategies employed by the host to clear infections. K. pneumoniae pathogenesis depends upon the interactions between the microbe and each of these host defenses, and it is becoming increasingly apparent that bacterial genetic diversity impacts the outcomes of these interactions. Here, we highlight recent advances in our understanding of K. pneumoniae pathogenesis, with a focus on how bacterial evolution and diversity impact K. pneumoniae interactions with mammalian innate immune host defenses. We also discuss outstanding questions regarding how K. pneumoniae can frustrate normal immune responses, capitalize upon states of immunocompromise, and cause infections with high mortality. are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range of infections that are often difficult to treat. These infections are caused by different pathotypes of , called either classical or hypervirulent strains. These two groups are genetically distinct, inhabit nonoverlapping geographies, and cause different types of harmful infections in humans. These distinct bacterial groups have also been found to interact differently with the host immune system. Initial innate immune defenses against infection include complement, macrophages, neutrophils, and monocytes; these defenses are primary strategies employed by the host to clear infections. pathogenesis depends upon the interactions between the microbe and each of these host defenses, and it is becoming increasingly apparent that bacterial genetic diversity impacts the outcomes of these interactions. Here, we highlight recent advances in our understanding of pathogenesis, with a focus on how bacterial evolution and diversity impact interactions with mammalian innate immune host defenses. We also discuss outstanding questions regarding how can frustrate normal immune responses, capitalize upon states of immunocompromise, and cause infections with high mortality.
Author	Budnick, James A Lee, Janet S Nordstrom, Hayley R Gonzalez-Ferrer, Shekina Peñaloza, Hernán F Van Tyne, Daria Bain, William G
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Snippet	are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range of infections that... Klebsiella pneumoniae are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range...
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SubjectTerms	Animals Disease Susceptibility Geography, Medical Global Health Host-Pathogen Interactions - immunology Humans Immunity, Innate Klebsiella Infections - epidemiology Klebsiella Infections - immunology Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - pathogenicity Klebsiella pneumoniae - physiology Population Surveillance Virulence
Title	Finding Order in the Chaos: Outstanding Questions in Klebsiella pneumoniae Pathogenesis
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