The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study

Ritonavir-boosted darunavir (DRV/r) and dolutegravir (DTG) are affected by induction of metabolizing enzymes and efflux transporters caused by rifampicin (RIF). This complicates the treatment of people living with HIV (PLWH) diagnosed with tuberculosis. Recent data showed that doubling DRV/r dose di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 66; H. 6; S. e0013622
Hauptverfasser:	De Nicolò, Amedeo, Calcagno, Andrea, Motta, Ilaria, De Vivo, Elisa, D'Avolio, Antonio, Di Perri, Giovanni, Wiesner, Lubbe, Ebrahim, Isma-Eel, Maartens, Gary, Orrell, Catherine, McIlleron, Helen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.06.2022
Schlagworte:	Anti-HIV Agents - pharmacokinetics Chromatography, Liquid Cross-Over Studies Darunavir - pharmacokinetics Heterocyclic Compounds, 3-Ring HIV Infections - drug therapy HIV Protease Inhibitors - pharmacology Humans Leukocytes, Mononuclear Oxazines Piperazines Pyridones Rifampin - pharmacokinetics Rifampin - therapeutic use Ritonavir - pharmacology Tandem Mass Spectrometry rifampicin drug interactions pharmacokinetics darunavir dolutegravir PBMC drug-drug interaction
ISSN:	1098-6596, 1098-6596
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!