Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection

The World Health Organization (WHO) recently recommended that linezolid be prioritized in treatment regimens for drug-resistant tuberculosis (TB), but there are limited data on its pharmacokinetics (PK) in patients with this disease. We conducted an observational study to explore covariate effects o...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 63; H. 3
Hauptverfasser:	Wasserman, Sean, Denti, Paolo, Brust, James C M, Abdelwahab, Mahmoud, Hlungulu, Siphokazi, Wiesner, Lubbe, Norman, Jennifer, Sirgel, Frederick A, Warren, Robin M, Esmail, Aliasgar, Dheda, Keertan, Gandhi, Neel R, Meintjes, Graeme, Maartens, Gary
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2019
Schlagworte:	Adult Antitubercular Agents - administration & dosage Antitubercular Agents - pharmacokinetics Antitubercular Agents - therapeutic use Female Humans Linezolid - administration & dosage Linezolid - pharmacokinetics Linezolid - therapeutic use Male Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Prospective Studies South Africa Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Pulmonary - drug therapy South Africa linezolid drug-resistant tuberculosis
ISSN:	1098-6596, 1098-6596
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