Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted states

Itraconazole is an orally active antifungal agent that has complex and highly variable absorption kinetics that is highly affected by food. This study aimed to develop a population pharmacokinetic model for itraconazole and the active metabolite hydroxyitraconazole, in particular, quantifying the ef...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 59; no. 9; p. 5681
Main Authors:	Abuhelwa, Ahmad Y, Foster, David J R, Mudge, Stuart, Hayes, David, Upton, Richard N
Format:	Journal Article
Language:	English
Published:	United States 01.09.2015
Subjects:	Administration, Oral Adolescent Adult Capsules - chemistry Cross-Over Studies Female Healthy Volunteers Humans Itraconazole - administration & dosage Itraconazole - analogs & derivatives Itraconazole - chemistry Itraconazole - pharmacokinetics Male Middle Aged Models, Theoretical Young Adult
ISSN:	1098-6596, 1098-6596
Online Access:	Get more information
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