Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis

Limited pharmacokinetic/pharmacodynamic (PK/PD) data exist on cycloserine in tuberculosis (TB) patients. We pooled several studies into a large PK data set to estimate the population PK parameters for cycloserine in TB patients. We also performed simulations to provide insight into optimizing the do...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 63; H. 5
Hauptverfasser:	Alghamdi, Wael A, Alsultan, Abdullah, Al-Shaer, Mohammad H, An, Guohua, Ahmed, Shahriar, Alkabab, Yosra, Banu, Sayera, Barbakadze, Ketevan, Houpt, Eric, Kipiani, Maia, Mikiashvili, Lali, Schmidt, Stephan, Heysell, Scott K, Kempker, Russell R, Cegielski, J Peter, Peloquin, Charles A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.2019
Schlagworte:	Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Cycloserine - pharmacokinetics Cycloserine - therapeutic use Humans Microbial Sensitivity Tests Monte Carlo Method Tuberculosis - drug therapy Tuberculosis - metabolism Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - metabolism pharmacokinetics cycloserine target attainment pharmacodynamics drug-resistant tuberculosis
ISSN:	1098-6596, 1098-6596
Online-Zugang:	Weitere Angaben
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