Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood-Brain Barrier for Noninvasive Brain Imaging

The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of penetration and level of resolution. Since the blood-brain barrier (BBB) prevents most molecules from entering the central nervous system, NIR-I...

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Vydáno v:Journal of the American Chemical Society Ročník 144; číslo 51; s. 23668 - 23676
Hlavní autoři: Wang, Shichao, Shi, Hui, Wang, Lushun, Loredo, Axel, Bachilo, Sergei M., Wu, William, Tian, Zeru, Chen, Yuda, Weisman, R. Bruce, Zhang, Xuanjun, Cheng, Zhen, Xiao, Han
Médium: Journal Article
Jazyk:angličtina
Vydáno: WASHINGTON Amer Chemical Soc 28.12.2022
Témata:
Animals
Blood-Brain Barrier
Brain - diagnostic imaging
Chemistry
Chemistry, Multidisciplinary
Fluorescent Dyes
Mice
Neoplasms
Neuroimaging
Optical Imaging - methods
Physical Sciences
Science & Technology
SURGERY
MODALITY MRI
TUMORS
DELIVERY
ISSN:0002-7863, 1520-5126, 1520-5126
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Abstract The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of penetration and level of resolution. Since the blood-brain barrier (BBB) prevents most molecules from entering the central nervous system, NIR-II dyes with large molecular frameworks have limited applications for brain imaging. In this work, we developed a series of boron difluoride (BF2) formazanate NIR-II dyes, which had tunable photophysical properties, ultrahigh photostability, excellent biological stability, and strong brightness. Modulation of the aniline moiety of BF2 formazanate dyes significantly enhances their abilities to cross the BBB for noninvasive brain imaging. Furthermore, the intact mouse brain imaging and dynamic dye diffusion across the BBB were monitored using these BF2 formazanate dyes in the NIR-II region. In murine glioblastoma models, these dyes can differentiate tumors from normal brain tissues. We anticipate that this new type of small molecule will find potential applications in creating probes and drugs relevant to theranostic for brain pathologies.
AbstractList The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of penetration and level of resolution. Since the blood-brain barrier (BBB) prevents most molecules from entering the central nervous system, NIR-II dyes with large molecular frameworks have limited applications for brain imaging. In this work, we developed a series of boron difluoride (BF ) formazanate NIR-II dyes, which had tunable photophysical properties, ultrahigh photostability, excellent biological stability, and strong brightness. Modulation of the aniline moiety of BF formazanate dyes significantly enhances their abilities to cross the BBB for noninvasive brain imaging. Furthermore, the intact mouse brain imaging and dynamic dye diffusion across the BBB were monitored using these BF formazanate dyes in the NIR-II region. In murine glioblastoma models, these dyes can differentiate tumors from normal brain tissues. We anticipate that this new type of small molecule will find potential applications in creating probes and drugs relevant to theranostic for brain pathologies.
The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of penetration and level of resolution. Since the blood-brain barrier (BBB) prevents most molecules from entering the central nervous system, NIR-II dyes with large molecular frameworks have limited applications for brain imaging. In this work, we developed a series of boron difluoride (BF2) formazanate NIR-II dyes, which had tunable photophysical properties, ultrahigh photostability, excellent biological stability, and strong brightness. Modulation of the aniline moiety of BF2 formazanate dyes significantly enhances their abilities to cross the BBB for noninvasive brain imaging. Furthermore, the intact mouse brain imaging and dynamic dye diffusion across the BBB were monitored using these BF2 formazanate dyes in the NIR-II region. In murine glioblastoma models, these dyes can differentiate tumors from normal brain tissues. We anticipate that this new type of small molecule will find potential applications in creating probes and drugs relevant to theranostic for brain pathologies.The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of penetration and level of resolution. Since the blood-brain barrier (BBB) prevents most molecules from entering the central nervous system, NIR-II dyes with large molecular frameworks have limited applications for brain imaging. In this work, we developed a series of boron difluoride (BF2) formazanate NIR-II dyes, which had tunable photophysical properties, ultrahigh photostability, excellent biological stability, and strong brightness. Modulation of the aniline moiety of BF2 formazanate dyes significantly enhances their abilities to cross the BBB for noninvasive brain imaging. Furthermore, the intact mouse brain imaging and dynamic dye diffusion across the BBB were monitored using these BF2 formazanate dyes in the NIR-II region. In murine glioblastoma models, these dyes can differentiate tumors from normal brain tissues. We anticipate that this new type of small molecule will find potential applications in creating probes and drugs relevant to theranostic for brain pathologies.
The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of penetration and level of resolution. Since the blood-brain barrier (BBB) prevents most molecules from entering the central nervous system, NIR-II dyes with large molecular frameworks have limited applications for brain imaging. In this work, we developed a series of boron difluoride (BF2) formazanate NIR-II dyes, which had tunable photophysical properties, ultrahigh photostability, excellent biological stability, and strong brightness. Modulation of the aniline moiety of BF2 formazanate dyes significantly enhances their abilities to cross the BBB for noninvasive brain imaging. Furthermore, the intact mouse brain imaging and dynamic dye diffusion across the BBB were monitored using these BF2 formazanate dyes in the NIR-II region. In murine glioblastoma models, these dyes can differentiate tumors from normal brain tissues. We anticipate that this new type of small molecule will find potential applications in creating probes and drugs relevant to theranostic for brain pathologies.
Author Wu, William
Xiao, Han
Cheng, Zhen
Wang, Shichao
Shi, Hui
Chen, Yuda
Loredo, Axel
Tian, Zeru
Zhang, Xuanjun
Bachilo, Sergei M.
Weisman, R. Bruce
Wang, Lushun
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  surname: Wang
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  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  surname: Shi
  fullname: Shi, Hui
  organization: Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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  orcidid: 0000-0002-8373-2199
  surname: Wang
  fullname: Wang, Lushun
  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  givenname: Axel
  surname: Loredo
  fullname: Loredo, Axel
  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  givenname: Sergei M.
  orcidid: 0000-0001-5236-1383
  surname: Bachilo
  fullname: Bachilo, Sergei M.
  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  surname: Chen
  fullname: Chen, Yuda
  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  givenname: R. Bruce
  orcidid: 0000-0001-6452-1778
  surname: Weisman
  fullname: Weisman, R. Bruce
  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
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  givenname: Xuanjun
  orcidid: 0000-0001-6452-1778
  surname: Zhang
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  organization: Univ Macau, Fac Hlth Sci, MOE Frontiers Sci Ctr Precis Oncol, Macau, Peoples R China
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  givenname: Han
  orcidid: 0000-0002-4311-971X
  surname: Xiao
  fullname: Xiao, Han
  email: han.xiao@rice.edu
  organization: Rice Univ, Dept Chem, Houston, TX 77005 USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36511618$$D View this record in MEDLINE/PubMed
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MODALITY MRI
TUMORS
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Snippet The second near-infrared (NIR-II, 1000-1700 nm) fluorescent probes have significant advantages over visible or NIR-I (600-900 nm) imaging for both depth of...
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SubjectTerms Animals
Blood-Brain Barrier
Brain - diagnostic imaging
Chemistry
Chemistry, Multidisciplinary
Fluorescent Dyes
Mice
Neoplasms
Neuroimaging
Optical Imaging - methods
Physical Sciences
Science & Technology
Title Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood-Brain Barrier for Noninvasive Brain Imaging
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