Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis

Levofloxacin is increasingly used in the treatment of multidrug-resistant tuberculosis (MDR-TB). There are limited pediatric pharmacokinetic data to inform dose selection for children. Children routinely receiving levofloxacin (250-mg adult tablets) for MDR-TB prophylaxis or disease in Cape Town, So...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 62; H. 2
Hauptverfasser:	Denti, Paolo, Garcia-Prats, Anthony J, Draper, Heather R, Wiesner, Lubbe, Winckler, Jana, Thee, Stephanie, Dooley, Kelly E, Savic, Rada M, McIlleron, Helen M, Schaaf, H Simon, Hesseling, Anneke C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2018
Schlagworte:	Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active Antitubercular Agents - blood Antitubercular Agents - pharmacokinetics Antitubercular Agents - pharmacology Area Under Curve Child Child, Preschool Coinfection Drug Administration Schedule Drug Dosage Calculations Female HIV - drug effects HIV - growth & development HIV Infections - blood HIV Infections - drug therapy HIV Infections - virology Humans Infant Levofloxacin - blood Levofloxacin - pharmacokinetics Levofloxacin - pharmacology Male Models, Statistical Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - growth & development Prospective Studies South Africa Tablets Tuberculosis, Multidrug-Resistant - blood Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology South Africa allometric scaling maturation dosing recommendations fluoroquinolones population PK modeling NONMEM pediatric
ISSN:	1098-6596, 1098-6596
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