Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?

Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal d...

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Bibliographic Details

Published in:	Antimicrobial agents and chemotherapy Vol. 63; no. 6
Main Authors:	Sekaggya-Wiltshire, Christine, Chirehwa, Maxwell, Musaazi, Joseph, von Braun, Amrei, Buzibye, Allan, Muller, Daniel, Gutteck, Ursula, Motta, Ilaria, Calcagno, Andrea, Fehr, Jan S, Kambugu, Andrew, Castelnuovo, Barbara, Lamorde, Mohammed, Denti, Paolo
Format:	Journal Article
Language:	English
Published:	United States 01.06.2019
Subjects:	pharmacokinetics Monolix antitubercular drugs pharmacometrics
ISSN:	1098-6596, 1098-6596
Online Access:	Get more information
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