Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers

MMV390048 is a novel antimalarial compound that inhibits phosphatidylinositol-4-kinase. The safety, tolerability, pharmacokinetic profile, and antimalarial activity of MMV390048 were determined in healthy volunteers in three separate studies. A first-in-human, double-blind, randomized, placebo-contr...

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Vydané v:	Antimicrobial agents and chemotherapy Ročník 64; číslo 4
Hlavní autori:	Sinxadi, Phumla, Donini, Cristina, Johnstone, Hilary, Langdon, Grant, Wiesner, Lubbe, Allen, Elizabeth, Duparc, Stephan, Chalon, Stephan, McCarthy, James S, Lorch, Ulrike, Chibale, Kelly, Möhrle, Jörg, Barnes, Karen I
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 24.03.2020
Predmet:	1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors Adult Aminopyridines - adverse effects Aminopyridines - pharmacokinetics Aminopyridines - pharmacology Antimalarials - adverse effects Antimalarials - pharmacokinetics Antimalarials - pharmacology Clinical Trials, Phase I as Topic Double-Blind Method Female Healthy Volunteers Humans Malaria, Falciparum - drug therapy Male Plasmodium falciparum - drug effects Sulfones - adverse effects Sulfones - pharmacokinetics Sulfones - pharmacology phosphatidylinositol-4-kinase Plasmodium falciparum volunteer infection study first-in-human safety MMV390048 pharmacokinetics malaria
ISSN:	1098-6596, 1098-6596
On-line prístup:	Zistit podrobnosti o prístupe
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