Catalysis of oxidative protein folding by small-molecule diselenides

The production of recombinant, disulfide-containing proteins often requires oxidative folding in vitro. Here, we show that diselenides, such as selenoglutathione, catalyze oxidative protein folding by O 2. Substantially lower concentrations of a redox buffer composed of selenoglutathione and the thi...

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Veröffentlicht in:	Biochemistry (Easton) Jg. 47; H. 27; S. 6985
Hauptverfasser:	Beld, Joris, Woycechowsky, Kenneth J, Hilvert, Donald
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 08.07.2008
Schlagworte:	Catalysis Glutathione - metabolism Kinetics Oxidation-Reduction Protein Folding Ribonuclease, Pancreatic - chemistry Ribonuclease, Pancreatic - metabolism Selenium Compounds - metabolism
ISSN:	1520-4995, 1520-4995
Online-Zugang:	Weitere Angaben
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