T Cell Fate at the Single-Cell Level

T cell responses display two key characteristics. First, a small population of epitope-specific naive T cells expands by several orders of magnitude. Second, the T cells within this proliferating population take on diverse functional and phenotypic properties that determine their ability to exert ef...

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Vydáno v:	Annual review of immunology Ročník 34; s. 65 - 92
Hlavní autoři:	Buchholz, Veit R, Schumacher, Ton N M, Busch, Dirk H
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 20.05.2016
Témata:	Adult Stem Cells - immunology Animals Biodiversity Cell Differentiation Cell Lineage Cell Proliferation Cultural Diversity Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Humans Immunologic Memory Immunotherapy - methods Lymphocyte Activation Single-Cell Analysis - methods T-Lymphocytes - immunology robustness stochasticity T cell differentiation T cell memory immunotherapy stemness
ISSN:	1545-3278
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Popis
Shrnutí:	T cell responses display two key characteristics. First, a small population of epitope-specific naive T cells expands by several orders of magnitude. Second, the T cells within this proliferating population take on diverse functional and phenotypic properties that determine their ability to exert effector functions and contribute to T cell memory. Recent technological advances in lineage tracing allow us for the first time to study these processes in vivo at single-cell resolution. Here, we summarize resulting data demonstrating that although epitope-specific T cell responses are reproducibly similar at the population level, expansion potential and diversification patterns of the offspring derived from individual T cells are highly variable during both primary and recall immune responses. In spite of this stochastic response variation, individual memory T cells can serve as adult stem cells that provide robust regeneration of an epitope-specific tissue through population averaging. We discuss the relevance of these findings for T cell memory formation and clinical immunotherapy.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1545-3278
DOI:	10.1146/annurev-immunol-032414-112014