Synthesis of [ 18 F]PS13 and Evaluation as a PET Radioligand for Cyclooxygenase-1 in Monkey

Cyclooxygenase-1 (COX-1) and its isozyme COX-2 are key enzymes in the syntheses of prostanoids. Imaging of COX-1 and COX-2 selective radioligands with positron emission tomography (PET) may clarify how these enzymes are involved in inflammatory conditions and assist in the discovery of improved anti...

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Bibliographic Details
Published in:	ACS chemical neuroscience Vol. 12; no. 3; p. 517
Main Authors:	Taddei, Carlotta, Morse, Cheryl L, Kim, Min-Jeong, Liow, Jeih-San, Montero Santamaria, Jose, Zhang, Andrea, Manly, Lester S, Zanotti-Fregonara, Paolo, Gladding, Robert L, Zoghbi, Sami S, Innis, Robert B, Pike, Victor W
Format:	Journal Article
Language:	English
Published:	United States 03.02.2021
Subjects:	Animals Brain - diagnostic imaging Brain - metabolism Carbon Radioisotopes Cyclooxygenase 1 - metabolism Fluorides Fluorine Radioisotopes Positron-Emission Tomography Radiopharmaceuticals PS13 brain imaging radioligand COX-1 Fluorine-18 nucleophilic addition PET
ISSN:	1948-7193
Online Access:	Get more information
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