New Insights into Gene Delivery to Human Neuronal Precursor NT2 Cells: A Comparative Study between Lipoplexes, Nioplexes, and Polyplexes

The transfection of human NTera2/D1 teratocarcinoma-derived cell line (or NT2 cells) represents a promising strategy for the delivery of exogenous proteins or biological agents into the central nervous system (CNS). The development of suitable nonviral vectors with high transfection efficiencies req...

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Veröffentlicht in:	Molecular pharmaceutics Jg. 12; H. 11; S. 4056 - 4066
Hauptverfasser:	Agirre, Mireia, Ojeda, Edilberto, Zarate, Jon, Puras, Gustavo, Grijalvo, Santiago, Eritja, Ramón, García del Caño, Gontzal, Barrondo, Sergio, González-Burguera, Imanol, López de Jesús, Maider, Sallés, Joan, Pedraz, José Luis
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 02.11.2015
Schlagworte:	Cell Survival Embryonal Carcinoma Stem Cells - metabolism Embryonal Carcinoma Stem Cells - pathology Endocytosis - physiology Gene Transfer Techniques Genetic Therapy - methods Green Fluorescent Proteins - metabolism Humans Lipids - chemistry Liposomes - chemistry Neurons - metabolism Neurons - pathology Plasmids - administration & dosage Polymers - chemistry Transfection endocytosis pCMS-EGFP nonviral vectors NTera2/D1 cells transfection
ISSN:	1543-8392
Online-Zugang:	Weitere Angaben
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