Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis

Caspases are cysteine proteases that specifically cleave Asp-Xxx bonds. They are key agents in inflammation and apoptosis and are attractive targets for therapy against inflammation, neurodegeneration, ischemia, and cancer. Many caspase structures are known, but most involve either peptide or protei...

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Vydané v:	Journal of medicinal chemistry Ročník 47; číslo 10; s. 2466
Hlavní autori:	Becker, Joseph W, Rotonda, Jennifer, Soisson, Stephen M, Aspiotis, Renee, Bayly, Christopher, Francoeur, Sébastien, Gallant, Michel, Garcia-Calvo, Marga, Giroux, Andre, Grimm, Erich, Han, Yongxin, McKay, Dan, Nicholson, Donald W, Peterson, Erin, Renaud, Johanne, Roy, Sophie, Thornberry, Nancy, Zamboni, Robert
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 06.05.2004
Predmet:	Caspase 3 Caspase Inhibitors Caspases - chemistry Crystallography, X-Ray Enzyme Inhibitors - chemistry Heterocyclic Compounds, 3-Ring - chemistry Ligands Models, Molecular Molecular Mimicry Molecular Structure Niacin - analogs & derivatives Niacin - chemistry Oligopeptides - chemistry Peptides - chemistry Protein Conformation Pyrazines - chemistry Structure-Activity Relationship
ISSN:	0022-2623
On-line prístup:	Zistit podrobnosti o prístupe
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