Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis

Caspases are cysteine proteases that specifically cleave Asp-Xxx bonds. They are key agents in inflammation and apoptosis and are attractive targets for therapy against inflammation, neurodegeneration, ischemia, and cancer. Many caspase structures are known, but most involve either peptide or protei...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 47; no. 10; p. 2466
Main Authors:	Becker, Joseph W, Rotonda, Jennifer, Soisson, Stephen M, Aspiotis, Renee, Bayly, Christopher, Francoeur, Sébastien, Gallant, Michel, Garcia-Calvo, Marga, Giroux, Andre, Grimm, Erich, Han, Yongxin, McKay, Dan, Nicholson, Donald W, Peterson, Erin, Renaud, Johanne, Roy, Sophie, Thornberry, Nancy, Zamboni, Robert
Format:	Journal Article
Language:	English
Published:	United States 06.05.2004
Subjects:	Caspase 3 Caspase Inhibitors Caspases - chemistry Crystallography, X-Ray Enzyme Inhibitors - chemistry Heterocyclic Compounds, 3-Ring - chemistry Ligands Models, Molecular Molecular Mimicry Molecular Structure Niacin - analogs & derivatives Niacin - chemistry Oligopeptides - chemistry Peptides - chemistry Protein Conformation Pyrazines - chemistry Structure-Activity Relationship
ISSN:	0022-2623
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!