Familial clustering of tic disorders and obsessive-compulsive disorder
Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important...
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| Vydané v: | JAMA psychiatry (Chicago, Ill.) Ročník 72; číslo 4; s. 359 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
01.04.2015
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| Abstract | Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important step in understanding the causes of these disorders.
To determine familial recurrence for TS/CT and OCD using a national epidemiologic sample.
We performed a population-based study of national health registries in Denmark, including all individuals (n = 1 741 271) born in Denmark from January 1, 1980, through December 31, 2007, and followed up through December 31, 2013. We identified those with TS/CT and/or OCD.
The prevalence of TS/CT and OCD and relative recurrence risk (RRR) for TS/CT or OCD among individuals with an oldest sibling or a parent diagnosed as having TS/CT or OCD compared with individuals without an affected oldest sibling or an affected parent.
In this sample, 5596 individuals were diagnosed as having TS/CT; 6191, OCD; and 412, both disorders. The overall cohort prevalence of TS/CT was 0.42% (95% CI, 0.41%-0.43%) and of OCD, 0.84% (95% CI, 0.81%-0.87%). The mean sibling recurrence risk for TS/CT across all birth years was 9.88% (95% CI, 8.02%-12.16%) and for OCD, 4.01% (95% CI, 2.78%-5.76%). The sibling RRR for TS/CT was 18.63 (95% CI, 15.34-22.63). In contrast, the sibling RRR for OCD was 4.89 (95% CI, 3.45-6.93). The parent-offspring RRR for TS/CT was 61.02 (95% CI, 44.43-83.82), whereas the parent-offspring RRR for OCD was 6.25 (95% CI, 4.82-8.11). The sibling and parent-offspring cross-disorder risks were also significant, ranging from 3.20 (95% CI, 2.22-4.62) to 10.27 (95% CI, 5.17-20.39).
Tourette syndrome/CT and OCD cluster in families. The familial aggregation of TS/CT is profound and substantially higher than the familial aggregation for OCD. The recurrence risk estimates provide an important clinical framework for identifying individuals at risk and provide insights into the causes of these disorders. |
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| AbstractList | Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important step in understanding the causes of these disorders.
To determine familial recurrence for TS/CT and OCD using a national epidemiologic sample.
We performed a population-based study of national health registries in Denmark, including all individuals (n = 1 741 271) born in Denmark from January 1, 1980, through December 31, 2007, and followed up through December 31, 2013. We identified those with TS/CT and/or OCD.
The prevalence of TS/CT and OCD and relative recurrence risk (RRR) for TS/CT or OCD among individuals with an oldest sibling or a parent diagnosed as having TS/CT or OCD compared with individuals without an affected oldest sibling or an affected parent.
In this sample, 5596 individuals were diagnosed as having TS/CT; 6191, OCD; and 412, both disorders. The overall cohort prevalence of TS/CT was 0.42% (95% CI, 0.41%-0.43%) and of OCD, 0.84% (95% CI, 0.81%-0.87%). The mean sibling recurrence risk for TS/CT across all birth years was 9.88% (95% CI, 8.02%-12.16%) and for OCD, 4.01% (95% CI, 2.78%-5.76%). The sibling RRR for TS/CT was 18.63 (95% CI, 15.34-22.63). In contrast, the sibling RRR for OCD was 4.89 (95% CI, 3.45-6.93). The parent-offspring RRR for TS/CT was 61.02 (95% CI, 44.43-83.82), whereas the parent-offspring RRR for OCD was 6.25 (95% CI, 4.82-8.11). The sibling and parent-offspring cross-disorder risks were also significant, ranging from 3.20 (95% CI, 2.22-4.62) to 10.27 (95% CI, 5.17-20.39).
Tourette syndrome/CT and OCD cluster in families. The familial aggregation of TS/CT is profound and substantially higher than the familial aggregation for OCD. The recurrence risk estimates provide an important clinical framework for identifying individuals at risk and provide insights into the causes of these disorders. Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important step in understanding the causes of these disorders.IMPORTANCETourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) overlap in their phenomenological features and often co-occur in affected individuals and families. Understanding how these disorders cluster in families provides important clinical information and is an important step in understanding the causes of these disorders.To determine familial recurrence for TS/CT and OCD using a national epidemiologic sample.OBJECTIVETo determine familial recurrence for TS/CT and OCD using a national epidemiologic sample.We performed a population-based study of national health registries in Denmark, including all individuals (n = 1 741 271) born in Denmark from January 1, 1980, through December 31, 2007, and followed up through December 31, 2013. We identified those with TS/CT and/or OCD.DESIGN, SETTING, AND PARTICIPANTSWe performed a population-based study of national health registries in Denmark, including all individuals (n = 1 741 271) born in Denmark from January 1, 1980, through December 31, 2007, and followed up through December 31, 2013. We identified those with TS/CT and/or OCD.The prevalence of TS/CT and OCD and relative recurrence risk (RRR) for TS/CT or OCD among individuals with an oldest sibling or a parent diagnosed as having TS/CT or OCD compared with individuals without an affected oldest sibling or an affected parent.MAIN OUTCOMES AND MEASURESThe prevalence of TS/CT and OCD and relative recurrence risk (RRR) for TS/CT or OCD among individuals with an oldest sibling or a parent diagnosed as having TS/CT or OCD compared with individuals without an affected oldest sibling or an affected parent.In this sample, 5596 individuals were diagnosed as having TS/CT; 6191, OCD; and 412, both disorders. The overall cohort prevalence of TS/CT was 0.42% (95% CI, 0.41%-0.43%) and of OCD, 0.84% (95% CI, 0.81%-0.87%). The mean sibling recurrence risk for TS/CT across all birth years was 9.88% (95% CI, 8.02%-12.16%) and for OCD, 4.01% (95% CI, 2.78%-5.76%). The sibling RRR for TS/CT was 18.63 (95% CI, 15.34-22.63). In contrast, the sibling RRR for OCD was 4.89 (95% CI, 3.45-6.93). The parent-offspring RRR for TS/CT was 61.02 (95% CI, 44.43-83.82), whereas the parent-offspring RRR for OCD was 6.25 (95% CI, 4.82-8.11). The sibling and parent-offspring cross-disorder risks were also significant, ranging from 3.20 (95% CI, 2.22-4.62) to 10.27 (95% CI, 5.17-20.39).RESULTSIn this sample, 5596 individuals were diagnosed as having TS/CT; 6191, OCD; and 412, both disorders. The overall cohort prevalence of TS/CT was 0.42% (95% CI, 0.41%-0.43%) and of OCD, 0.84% (95% CI, 0.81%-0.87%). The mean sibling recurrence risk for TS/CT across all birth years was 9.88% (95% CI, 8.02%-12.16%) and for OCD, 4.01% (95% CI, 2.78%-5.76%). The sibling RRR for TS/CT was 18.63 (95% CI, 15.34-22.63). In contrast, the sibling RRR for OCD was 4.89 (95% CI, 3.45-6.93). The parent-offspring RRR for TS/CT was 61.02 (95% CI, 44.43-83.82), whereas the parent-offspring RRR for OCD was 6.25 (95% CI, 4.82-8.11). The sibling and parent-offspring cross-disorder risks were also significant, ranging from 3.20 (95% CI, 2.22-4.62) to 10.27 (95% CI, 5.17-20.39).Tourette syndrome/CT and OCD cluster in families. The familial aggregation of TS/CT is profound and substantially higher than the familial aggregation for OCD. The recurrence risk estimates provide an important clinical framework for identifying individuals at risk and provide insights into the causes of these disorders.CONCLUSIONS AND RELEVANCETourette syndrome/CT and OCD cluster in families. The familial aggregation of TS/CT is profound and substantially higher than the familial aggregation for OCD. The recurrence risk estimates provide an important clinical framework for identifying individuals at risk and provide insights into the causes of these disorders. |
| Author | Reichenberg, Abraham Buxbaum, Joseph D Nissen, Judith B Gair, Shannon L Schendel, Diana E Parner, Erik T Grice, Dorothy E Hansen, Stefan N Nikolajsen, Kathrine H Browne, Heidi A |
| Author_xml | – sequence: 1 givenname: Heidi A surname: Browne fullname: Browne, Heidi A organization: Division of Tics, OCD, and Related Disorders, Icahn School of Medicine at Mount Sinai, New York, New York2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York3Friedman Brain Institute, Icahn School of Medicine at Mount Sin – sequence: 2 givenname: Stefan N surname: Hansen fullname: Hansen, Stefan N organization: Department of Public Health, Section for Biostatistics, Aarhus University, Aarhus, Denmark – sequence: 3 givenname: Joseph D surname: Buxbaum fullname: Buxbaum, Joseph D organization: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York3Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York5Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount – sequence: 4 givenname: Shannon L surname: Gair fullname: Gair, Shannon L organization: Division of Tics, OCD, and Related Disorders, Icahn School of Medicine at Mount Sinai, New York, New York2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York3Friedman Brain Institute, Icahn School of Medicine at Mount Sin – sequence: 5 givenname: Judith B surname: Nissen fullname: Nissen, Judith B organization: Children and Adolescent Psychiatric Center, Aarhus University Hospital, Aarhus, Denmark – sequence: 6 givenname: Kathrine H surname: Nikolajsen fullname: Nikolajsen, Kathrine H organization: Children and Adolescent Psychiatric Center, Aarhus University Hospital, Aarhus, Denmark – sequence: 7 givenname: Diana E surname: Schendel fullname: Schendel, Diana E organization: Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark11Department of Economics and Business and National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark12Lundbeck Foundation Initiative for Integra – sequence: 8 givenname: Abraham surname: Reichenberg fullname: Reichenberg, Abraham organization: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York5Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York8Mindich Child Health and Development Institute, Icahn School – sequence: 9 givenname: Erik T surname: Parner fullname: Parner, Erik T organization: Department of Public Health, Section for Biostatistics, Aarhus University, Aarhus, Denmark – sequence: 10 givenname: Dorothy E surname: Grice fullname: Grice, Dorothy E organization: Division of Tics, OCD, and Related Disorders, Icahn School of Medicine at Mount Sinai, New York, New York2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York3Friedman Brain Institute, Icahn School of Medicine at Mount Sin |
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| SubjectTerms | Denmark - epidemiology Family Health - statistics & numerical data Female Humans Male Obsessive-Compulsive Disorder - complications Obsessive-Compulsive Disorder - epidemiology Prevalence Registries Risk Factors Tic Disorders - complications Tic Disorders - epidemiology |
| Title | Familial clustering of tic disorders and obsessive-compulsive disorder |
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