Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternativ...

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Vydáno v:Chemical reviews Ročník 121; číslo 21; s. 13454
Hlavní autoři: Pham, Thanh Chung, Nguyen, Van-Nghia, Choi, Yeonghwan, Lee, Songyi, Yoon, Juyoung
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 10.11.2021
Témata:
Humans
Nanotechnology
Neoplasms - drug therapy
Photochemotherapy - methods
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Reactive Oxygen Species
ISSN:1520-6890, 1520-6890
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Shrnutí:This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.
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ISSN:1520-6890
1520-6890
DOI:10.1021/acs.chemrev.1c00381