Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

The transient receptor potential (TRP) family of ion channels comprises nonselective cation channels that respond to a wide range of chemical and thermal stimuli. TRPM8, a member of the melastatin subfamily, is activated by cold temperatures (<28 degrees C), and antagonists of this channel have t...

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Veröffentlicht in:	ACS medicinal chemistry letters Jg. 6; H. 4; S. 419 - 424
Hauptverfasser:	Andrews, Mark D., af Forselles, Kerry, Beaumont, Kevin, Galan, Sebastien R. G., Glossop, Paul A., Grenie, Mathilde, Jessiman, Alan, Kenyon, Amy S., Lunn, Graham, Maw, Graham, Owen, Robert M., Pryde, David C., Roberts, Dannielle, Thien Duc Tran
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	WASHINGTON Amer Chemical Soc 09.04.2015
Schlagworte:	Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology pain DESIGN SERIES PP-05105679 clinical tool BODY-TEMPERATURE thermoregulation TRP channel PHARMACOLOGICAL BLOCKADE DRUG-DISCOVERY POTENT hypothermia ion channel CHANNELS TRPM8 PF-05105679
ISSN:	1948-5875, 1948-5875
Online-Zugang:	Weitere Angaben
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