CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)‑one-3-carboxamides

We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold very suitable for the development of new CB2 receptor potent and selective ligands. In this paper we describe a number of additional derivatives in which the same central scaffold has been variously functionalize...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 57; no. 21; pp. 8777 - 8791
Main Authors:	Lucchesi, Valentina, Hurst, Dow P, Shore, Derek M, Bertini, Simone, Ehrmann, Brandie M, Allarà, Marco, Lawrence, Lyle, Ligresti, Alessia, Minutolo, Filippo, Saccomanni, Giuseppe, Sharir, Haleli, Macchia, Marco, Di Marzo, Vincenzo, Abood, Mary E, Reggio, Patricia H, Manera, Clementina
Format:	Journal Article
Language:	English
Published:	WASHINGTON American Chemical Society 13.11.2014 Amer Chemical Soc
Subjects:	Cell Line, Tumor Chemistry, Medicinal Humans Life Sciences & Biomedicine Ligands Models, Molecular Molecular Docking Simulation Naphthyridines - chemical synthesis Naphthyridines - chemistry Pharmacology & Pharmacy Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - chemistry Science & Technology Structure-Activity Relationship SYSTEM CB2 RECEPTORS FUNCTIONAL EXPRESSION 1ST POTENT RHODOPSIN CREVICE BINDING RATIONAL DESIGN
ISSN:	0022-2623, 1520-4804, 1520-4804
Online Access:	Get full text
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