CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)‑one-3-carboxamides

We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold very suitable for the development of new CB2 receptor potent and selective ligands. In this paper we describe a number of additional derivatives in which the same central scaffold has been variously functionalize...

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Veröffentlicht in:	Journal of medicinal chemistry Jg. 57; H. 21; S. 8777 - 8791
Hauptverfasser:	Lucchesi, Valentina, Hurst, Dow P, Shore, Derek M, Bertini, Simone, Ehrmann, Brandie M, Allarà, Marco, Lawrence, Lyle, Ligresti, Alessia, Minutolo, Filippo, Saccomanni, Giuseppe, Sharir, Haleli, Macchia, Marco, Di Marzo, Vincenzo, Abood, Mary E, Reggio, Patricia H, Manera, Clementina
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	WASHINGTON American Chemical Society 13.11.2014 Amer Chemical Soc
Schlagworte:	Cell Line, Tumor Chemistry, Medicinal Humans Life Sciences & Biomedicine Ligands Models, Molecular Molecular Docking Simulation Naphthyridines - chemical synthesis Naphthyridines - chemistry Pharmacology & Pharmacy Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - chemistry Science & Technology Structure-Activity Relationship SYSTEM CB2 RECEPTORS FUNCTIONAL EXPRESSION 1ST POTENT RHODOPSIN CREVICE BINDING RATIONAL DESIGN
ISSN:	0022-2623, 1520-4804, 1520-4804
Online-Zugang:	Volltext
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