Potent Anti-Inflammatory, Arylpyrazole-Based Glucocorticoid Receptor Agonists That Do Not Impair Insulin Secretion

Glucocorticoids (GCs) are widely used in medicine for their role in the treatment of autoimmune-mediated conditions, certain cancers, and organ transplantation. The transcriptional activities GCs elicit include transrepression, postulated to be responsible for the anti-inflammatory activity, and tra...

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Vydané v:	ACS medicinal chemistry letters Ročník 12; číslo 10; s. 1568 - 1577
Hlavní autori:	Kennedy, Brandon J., Lato, Ashley M., Fisch, Alexander R., Burke, Susan J., Kirkland, Justin K., Prevatte, Carson W., Dunlap, Lee E., Smith, Russell T., Vogiatzis, Konstantinos D., Collier, J. Jason, Campagna, Shawn R.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	WASHINGTON Amer Chemical Soc 14.10.2021
Predmet:	Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology ACTIVATION APPROXIMATION MODULATORS Drug-repositioning CORRELATION-ENERGY PREVENTION Inflammation KAPPA-B Glucocorticoid Insulin secretion N-arylpyrazole Transcriptional modifiers HYPERGLYCEMIA BASIS-SETS BINDING MOLECULAR-MECHANISMS
ISSN:	1948-5875, 1948-5875
On-line prístup:	Zistit podrobnosti o prístupe
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