Potent Anti-Inflammatory, Arylpyrazole-Based Glucocorticoid Receptor Agonists That Do Not Impair Insulin Secretion

Glucocorticoids (GCs) are widely used in medicine for their role in the treatment of autoimmune-mediated conditions, certain cancers, and organ transplantation. The transcriptional activities GCs elicit include transrepression, postulated to be responsible for the anti-inflammatory activity, and tra...

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Bibliographic Details
Published in:	ACS medicinal chemistry letters Vol. 12; no. 10; pp. 1568 - 1577
Main Authors:	Kennedy, Brandon J., Lato, Ashley M., Fisch, Alexander R., Burke, Susan J., Kirkland, Justin K., Prevatte, Carson W., Dunlap, Lee E., Smith, Russell T., Vogiatzis, Konstantinos D., Collier, J. Jason, Campagna, Shawn R.
Format:	Journal Article
Language:	English
Published:	WASHINGTON Amer Chemical Soc 14.10.2021
Subjects:	Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology ACTIVATION APPROXIMATION MODULATORS Drug-repositioning CORRELATION-ENERGY PREVENTION Inflammation KAPPA-B Glucocorticoid Insulin secretion N-arylpyrazole Transcriptional modifiers HYPERGLYCEMIA BASIS-SETS BINDING MOLECULAR-MECHANISMS
ISSN:	1948-5875, 1948-5875
Online Access:	Get more information
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