Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial

Coronary plaques that are prone to rupture and cause adverse cardiac events are characterized by large plaque burden, large lipid content, and thin fibrous caps. Statins can halt the progression of coronary atherosclerosis; however, the effect of the proprotein convertase subtilisin kexin type 9 inh...

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Bibliographic Details
Published in:	JAMA : the journal of the American Medical Association Vol. 327; no. 18; p. 1771
Main Authors:	Räber, Lorenz, Ueki, Yasushi, Otsuka, Tatsuhiko, Losdat, Sylvain, Häner, Jonas D, Lonborg, Jacob, Fahrni, Gregor, Iglesias, Juan F, van Geuns, Robert-Jan, Ondracek, Anna S, Radu Juul Jensen, Maria D, Zanchin, Christian, Stortecky, Stefan, Spirk, David, Siontis, George C M, Saleh, Lanja, Matter, Christian M, Daemen, Joost, Mach, François, Heg, Dik, Windecker, Stephan, Engstrøm, Thomas, Lang, Irene M, Koskinas, Konstantinos C
Format:	Journal Article
Language:	English
Published:	United States 10.05.2022
Subjects:	Aged Antibodies, Monoclonal, Humanized - therapeutic use Cholesterol, LDL Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - drug therapy Double-Blind Method Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Middle Aged Myocardial Infarction - complications Myocardial Infarction - drug therapy PCSK9 Inhibitors - therapeutic use Plaque, Atherosclerotic - complications Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - drug therapy Treatment Outcome
ISSN:	1538-3598, 1538-3598
Online Access:	Get more information
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