Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

Modulation of protein-protein interactions (PPIs) by small molecules has emerged as a valuable approach in drug discovery. Compared to direct inhibition, PPI stabilization is vastly underexplored but has strong advantages, including the ability to gain selectivity by targeting an interface formed on...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 141; no. 8; p. 3524
Main Authors:	Sijbesma, Eline, Hallenbeck, Kenneth K, Leysen, Seppe, de Vink, Pim J, Skóra, Lukasz, Jahnke, Wolfgang, Brunsveld, Luc, Arkin, Michelle R, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	United States 27.02.2019
ISSN:	1520-5126, 1520-5126
Online Access:	Get more information
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