Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

Modulation of protein-protein interactions (PPIs) by small molecules has emerged as a valuable approach in drug discovery. Compared to direct inhibition, PPI stabilization is vastly underexplored but has strong advantages, including the ability to gain selectivity by targeting an interface formed on...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society Jg. 141; H. 8; S. 3524
Hauptverfasser:	Sijbesma, Eline, Hallenbeck, Kenneth K, Leysen, Seppe, de Vink, Pim J, Skóra, Lukasz, Jahnke, Wolfgang, Brunsveld, Luc, Arkin, Michelle R, Ottmann, Christian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 27.02.2019
ISSN:	1520-5126, 1520-5126
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!