In vitro activity of antibiotic monotherapy and combination therapy with bacteriophages against Staphylococcus aureus LVAD-driveline infections

Current treatment strategies for S. aureus LVAD-driveline infections are based on in vitro antibiotic susceptibility of planktonic bacteria. However, LVAD infections are most often biofilm-related, which decreases antibiotic susceptibility significantly, resulting in discrepancies between in vitro a...

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Bibliographic Details
Published in:	Journal of clinical microbiology Vol. 63; no. 11; p. e0027225
Main Authors:	Molendijk, Michèle M., Verkaik, Nelianne J., de Vogel, Corné P., Lemmens-den Toom, Nicole, Knight, Gwenan M., Caliskan, Kadir, Bode, Lonneke G. M., Verbon, Annelies, Koopmans, Marion P. G., de Graaf, Miranda, van Wamel, Willem J. B.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 12.11.2025
Subjects:	Animal Models of Infection Anti-Bacterial Agents - pharmacology Antimicrobial Resistance Bacterial Infections Bacteriology Bacteriophage-Pathogen Interactions Bacteriophages Bacteriophages - physiology biofilm Biofilm-Associated Resistance Biofilms - drug effects Biofilms - growth & development Clinical Microbiology and Infectious Diseases Heart-Assist Devices - adverse effects Heart-Assist Devices - microbiology Humans isothermal microcalorimetry LVAD driveline infection Microbial Pathogenesis and Immunology Microbial Sensitivity Tests Outbreak Investigation in Healthcare Facilities Phage Therapy Phage Therapy - methods Prosthesis-Related Infections - microbiology Prosthesis-Related Infections - therapy Rifampin - pharmacology Staphylococcal Infections Staphylococcal Infections - microbiology Staphylococcal Infections - therapy Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Staphylococcus aureus - virology Staphylococcus Phages - physiology Trichinellosis Vaginal Fungal Infections Virology LVAD driveline infection Staphylococcus aureus bacteriophages biofilm isothermal microcalorimetry
ISSN:	0095-1137, 1098-660X, 1098-660X
Online Access:	Get full text
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