An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an ongoing public health challenge as a cause of acute illness and post-acute sequelae of COVID-19 (PASC, or long COVID). Our study identifies the RGD integrin-binding motif in the spike (S) protein as central to the cellular resp...

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Bibliographic Details
Published in:	Journal of virology Vol. 99; no. 9; p. e0043525
Main Authors:	Gracie, Nicholas P., Aggarwal, Anupriya, Luo, Rachel, Spicer, Mitchell, Idrees, Sobia, Ashley, Caroline L., Alca, Sibel, Ison, Timothy, Steain, Megan C., Patel, Karishma, Siddiquee, Rezwan, Low, Jason K. K., Mackay, Joel P., Denes, Christopher E., Neely, G. Gregory, Faiz, Alen, Turville, Stuart G., Newsome, Timothy P.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 23.09.2025
Subjects:	Amino Acid Motifs Angiotensin-Converting Enzyme 2 - metabolism Animals coronavirus COVID-19 COVID-19 - metabolism COVID-19 - virology Down-Regulation Editor’s Pick HEK293 Cells Humans integrins Interferons - metabolism Oligopeptides - metabolism Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism RGD (Arg-Gly-Asp) SARS-CoV-2 SARS-CoV-2 - metabolism Signal Transduction Smad3 Protein - metabolism Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism TGF-β Transforming Growth Factor beta - metabolism Virology Virus-Cell Interactions COVID-19 SARS-CoV-2 integrins IFN-β RGD (Arg-Gly-Asp) PAI-1 TGF-β coronavirus
ISSN:	0022-538X, 1098-5514, 1098-5514
Online Access:	Get full text
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