Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templates. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was almost as efficient a su...

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Veröffentlicht in:	Biochemistry (Easton) Jg. 31; H. 18; S. 4473
1. Verfasser:	Reardon, J E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 12.05.1992
Schlagworte:	Antiviral Agents - pharmacology Base Sequence Binding, Competitive Dideoxynucleotides HIV - enzymology Molecular Sequence Data Oligonucleotide Probes - chemistry Reverse Transcriptase Inhibitors RNA-Directed DNA Polymerase - chemistry Templates, Genetic Thionucleotides - chemistry Thymine Nucleotides - pharmacokinetics Thymine Nucleotides - pharmacology Zidovudine - analogs & derivatives Zidovudine - pharmacology
ISSN:	0006-2960
Online-Zugang:	Weitere Angaben
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