Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templates. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was almost as efficient a su...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 31; no. 18; p. 4473
Main Author:	Reardon, J E
Format:	Journal Article
Language:	English
Published:	United States 12.05.1992
Subjects:	Antiviral Agents - pharmacology Base Sequence Binding, Competitive Dideoxynucleotides HIV - enzymology Molecular Sequence Data Oligonucleotide Probes - chemistry Reverse Transcriptase Inhibitors RNA-Directed DNA Polymerase - chemistry Templates, Genetic Thionucleotides - chemistry Thymine Nucleotides - pharmacokinetics Thymine Nucleotides - pharmacology Zidovudine - analogs & derivatives Zidovudine - pharmacology
ISSN:	0006-2960
Online Access:	Get more information
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